Flow-induced shear strain in intima of porcine coronary arteries.

Flow-induced shear strain in intima of porcine coronary arteries. Research Abstract Details 

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Flow-induced shear strain in intima of porcine coronary arteries. Abstract Text:

Wei Zhang,Yi Liu,Ghassan S Kassab,

The in vivo circumferential strain has a small variation throughout the vascular system (aorta to arterioles). The axial strain has also been shown to be nearly the same as the circumferential strain under physiological loading. Since the endothelium is mechanically much softer than the media-adventitia in healthy arteries, the porcine intima was considered as a mechanically distinct layer from the media-adventitia in a two-layer computational model. Based on the simulation result, we hypothesize that the flow-induced shear strain in intima can be of similar value as the pressure-induced circumferential strain in healthy coronary arteries, even though the shear stress is orders of magnitude smaller than the circumferential stress. The nearly isotropic deformation (circumferential, axial, and shear strains) may have important implications for mechanical homeostasis of endothelial cells, mechanotransduction, growth, and remodeling of blood vessels.

Flow-induced shear strain in intima of porcine coronary arteries. Publishing Authors By Initials

W Zhang,Y Liu,GS Kassab,

For similar cardiovascular system: blood vessels: endothelium, vascular: tunica intima research abstracts see: cardiovascular system: blood vessels: endothelium, vascular: tunica intima research

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Flow-induced shear strain in intima of porcine coronary arteries. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of applied physiology (Bethesda, Md. : 198

VOLUME: 103

Page Numbers: 587-93

Journal Abbreviation: J. Appl. Physiol.

ISSN: 8750-7587

DAY: 24

MONTH: 05

YEAR: 2007

Flow-induced shear strain in intima of porcine coronary arteries. Information

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LANGUAGE: eng

NlmUniqueID: 8502536

Flow-induced shear strain in intima of porcine coronary arteries. Keywords Mesh Terms:

KEYWORDS: Tunica Intima

MESH TERMS: physiology

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Grant and Affiliation Information for Flow-induced shear strain in intima of porcine coronary arteries.

AFFILIATION: Dept. of Biomedical Engineering, Indiana University Purdue University Indianapolis, Indianapolis, Indianapolis 46202, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: 2 R01 HL055554-11

ACRONYM: HL

MEDLINETA: J Appl Physiol

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