Flow cytometric DNA analysis of 199 histologically favourable or unfavourable non-Hodgkin lymphomas.

Flow cytometric DNA analysis of 199 histologically favourable or unfavourable non-Hodgkin lymphomas. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Flow cytometric DNA analysis of 199 histologically favourable or unfavourable non-Hodgkin lymphomas. Abstract Text:

T Lehtinen,R Aine,M Lehtinen,O P Kallioniemi,T Leino,T Hakala,P Leinikki,M Alavaikko,

We have studied the nuclear DNA content of histologically favourable (n = 82) or unfavourable (n = 117) non-Hodgkin lymphomas (NHLs) diagnosed between 1957 and 1978 in the Tampere University Central Hospital. The DNA analysis was done by applying a trypsin digestion method to archival tumour samples. DNA aneuploidy was seen in 40 per cent of the unfavourable cases and in 10 per cent of the favourable cases, but varied considerably between different histological subtypes. The unfavourable cases showed high proliferative activity (S-phase fraction, SPF), while considerable variation in the SPF among the favourable NHLs was noted. Among the unfavourable NHLs, cases with DNA-aneuploid tumours had significantly (P less than 0.01) worse prognosis than stage and treatment matched cases with DNA-diploid tumours. In general, survival of the patients who had high SPF tumours was significantly lower compared with patients with low SPF tumours (P less than 0.01). However, SPF was not related to the prognosis in the unfavourable NHLs. We conclude that the flow cytometric DNA analysis revealed characteristic features in the favourable and unfavourable NHLs and may be useful in predicting the clinical outcome of patients.

Flow cytometric DNA analysis of 199 histologically favourable or unfavourable non-Hodgkin lymphomas. Publishing Authors By Initials

T Lehtinen,R Aine,M Lehtinen,OP Kallioniemi,T Leino,T Hakala,P Leinikki,M Alavaikko,

For similar diagnosis: prognosis research abstracts see: diagnosis: prognosis research

PUBMED ID PMID:

MEDLINE DATE:

Flow cytometric DNA analysis of 199 histologically favourable or unfavourable non-Hodgkin lymphomas. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of pathology

VOLUME: 157

Page Numbers: 27-36

Journal Abbreviation: J. Pathol.

ISSN: 0022-3417

DAY: 29

MONTH: Jan

YEAR: 1989

Flow cytometric DNA analysis of 199 histologically favourable or unfavourable non-Hodgkin lymphomas. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 204634

Flow cytometric DNA analysis of 199 histologically favourable or unfavourable non-Hodgkin lymphomas. Keywords Mesh Terms:

KEYWORDS: Prognosis

MESH TERMS: pathology

Chemical & Substance for Abstract: Flow cytometric DNA analysis of 199 histologically favourable or unfavourable non-Hodgkin lymphomas. Information

Substance Name: DNA

Registry Number: 9007-49-2

Grant and Affiliation Information for Flow cytometric DNA analysis of 199 histologically favourable or unfavourable non-Hodgkin lymphomas.

AFFILIATION: Department of Oncology, Tampere University Central Hospital, Finland.

Country: ENGLAND

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Pathol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Flow cytometric DNA analysis of 199 histologically favourable or unfavourable non-Hodgkin lymphomas Related Publications

• Effect of phenobarbital on hepatic injury induced by chronic carbon tetrachloride treatment.
• Flow cytometric DNA analysis of 199 histologically favourable or unfavourable non-Hodgkin lymphomas.
• Selective separation of mouse epidermal cells and cytophotometric estimation of their nuclear DNA.
• Spiral autogenous venous graft in the replacement of large vessels. An experimental study with special reference to replacement of the inferior vena cava.
• Value of free metaphase cell preparations in cytophotometric study of experimental skin carcinogenesis.