Flaxseed oil supplementation does not affect plasma lipoprotein concentration or particle size in human subjects.

Flaxseed oil supplementation does not affect plasma lipoprotein concentration or particle size in human subjects. Research Abstract Details 

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Flaxseed oil supplementation does not affect plasma lipoprotein concentration or particle size in human subjects. Abstract Text:

Charles R Harper,Megan C Edwards,Terry A Jacobson,

alpha-Linolenic acid (ALA) is a major dietary (n-3) fatty acid. Some clinical trials with ALA supplementation have shown reduced cardiovascular risk; however the specific cardioprotective mechanism is not known. We studied the effects of daily supplementation with ALA derived from flaxseed oil on concentrations of plasma LDL cholesterol, HDL cholesterol, intermediate density lipoprotein cholesterol, and lipid particle sizes. In a randomized double-blind trial, 56 participants were given 3 g/d of ALA from flaxseed oil in capsules (n = 31) or olive oil containing placebo capsules (n = 25) for 26 wk. Changes in plasma HDL cholesterol, LDL cholesterol, and triglyceride concentrations did not differ between the 2 groups at 26 wk. The adjusted plasma total cholesterol concentration at 26 wk was 0.45 mmol/L higher in the flaxseed oil group (5.43 +/- 0.03 mmol/L) compared with the olive oil group (5.17 +/- 0.07 mmol/L) (P = 0.026). ALA did not affect LDL, HDL, or IDL particle size; however, the concentrations of the large, less atherogenic LDL1 (P = 0.058) and LDL2 (P = 0.083) subfractions tended to be greater in the ALA group. In conclusion, ALA does not decrease CVD risk by altering lipoprotein particle size or plasma lipoprotein concentrations.

Flaxseed oil supplementation does not affect plasma lipoprotein concentration or particle size in human subjects. Publishing Authors By Initials

CR Harper,MC Edwards,TA Jacobson,

For similar lipids: fats: dietary fats: dietary fats, unsaturated: fatty acids, omega-3: alpha-linolenic acid research abstracts see: lipids: fats: dietary fats: dietary fats, unsaturated: fatty acids, omega-3: alpha-linolenic acid research

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Flaxseed oil supplementation does not affect plasma lipoprotein concentration or particle size in human subjects. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of nutrition

VOLUME: 136

Page Numbers: 2844-8

Journal Abbreviation: J. Nutr.

ISSN: 0022-3166

DAY: 3

MONTH: Nov

YEAR: 2006

Flaxseed oil supplementation does not affect plasma lipoprotein concentration or particle size in human subjects. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 404243

Flaxseed oil supplementation does not affect plasma lipoprotein concentration or particle size in human subjects. Keywords Mesh Terms:

KEYWORDS: alpha-Linolenic Acid

MESH TERMS: administration & dosage

Chemical & Substance for Abstract: Flaxseed oil supplementation does not affect plasma lipoprotein concentration or particle size in human subjects. Information

Substance Name: Linseed Oil

Registry Number: 8001-26-1

Grant and Affiliation Information for Flaxseed oil supplementation does not affect plasma lipoprotein concentration or particle size in human subjects.

AFFILIATION: Department of Medicine, Emory University, Atlanta, GA 30303, USA. charper@emory.edu

Country: United States

AGENCY: United States NCRR

GRANT: M01-RR00039

ACRONYM: RR

MEDLINETA: J Nutr

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