Flavin-containing monooxygenase 3 and human disease.

Flavin-containing monooxygenase 3 and human disease. Research Abstract Details 

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Flavin-containing monooxygenase 3 and human disease. Abstract Text:

Meike S Motika,Jun Zhang,John R Cashman,Meike S Motika,Jun Zhang,John R Cashman,

This review summarizes information concerning the association of the human flavin-containing monooxygenase 3 (FMO3) and human diseases. Human FMO3 oxygenates a wide variety of nucleophilic heteroatom-containing xenobiotics, including endogenous substrates and various clinically important drugs. In this article, the authors discuss the association of FMO3 with human disease, including: i) direct association of FMO3 genetic mutations to human genetic disease; ii) association of FMO3 genetic polymorphism to altered drug metabolism and, therefore, indirect association of FMO3 with drug therapeutic efficacy of human disease; and iii) the potential impact and/or effect of FMO3 transcriptional regulation during disease states. Even though many studies discussed for the latter two points are at a preliminary stage and require much more research to bring to a definite conclusion, the authors include these studies to stimulate general interest and invite further discussion.

Flavin-containing monooxygenase 3 and human disease. Publishing Authors By Initials

MS Motika,J Zhang,JR Cashman,MS Motika,J Zhang,JR Cashman,

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Flavin-containing monooxygenase 3 and human disease. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Expert opinion on drug metabolism & toxicology

VOLUME: 3

Page Numbers: 831-45

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ISSN: 1742-5255

DAY: 21

MONTH: Dec

YEAR: 2007

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LANGUAGE: eng

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AFFILIATION: Human Biomolecular Research Institute, 5310 Eastgate Mall, San Diego, CA 92121, USA +1 858 458 9305 ; +1 858 458 9311 ; jcashman@hbri.org.

Country: England

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MEDLINETA: Expert Opin Drug Metab Toxicol

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