First total synthesis of vialinin A, a novel and extremely potent inhibitor of TNF-alpha production.

First total synthesis of vialinin A, a novel and extremely potent inhibitor of TNF-alpha production. Research Abstract Details 

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First total synthesis of vialinin A, a novel and extremely potent inhibitor of TNF-alpha production. Abstract Text:

Yue Qi Ye,Hiroyuki Koshino,Jun-ichi Onose,Kunie Yoshikawa,Naoki Abe,Shunya Takahashi,

Vialinin A, a powerful inhibitor (IC50 90 pM) of TNF-alpha production, was synthesized from sesamol in 11 steps with 28% overall yield. The key reactions include a double Suzuki coupling of electron-rich aryl triflate with phenylboronic acid and an oxidative deprotection of bis-MOM ether. In addition, the related synthetic studies also suggest the necessity for structural revision of ganbajunin C, a positional isomer of vialinin A.

First total synthesis of vialinin A, a novel and extremely potent inhibitor of TNF-alpha production. Publishing Authors By Initials

YQ Ye,H Koshino,J Onose,K Yoshikawa,N Abe,S Takahashi,

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First total synthesis of vialinin A, a novel and extremely potent inhibitor of TNF-alpha production. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Organic letters

VOLUME: 9

Page Numbers: 4131-4

Journal Abbreviation: Org. Lett.

ISSN: 1523-7060

DAY: 12

MONTH: 09

YEAR: 2007

First total synthesis of vialinin A, a novel and extremely potent inhibitor of TNF-alpha production. Information

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LANGUAGE: eng

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Grant and Affiliation Information for First total synthesis of vialinin A, a novel and extremely potent inhibitor of TNF-alpha production.

AFFILIATION: RIKEN (The Institute of Physical and Chemical Research), Wako, Saitama 351-0198, Japan.

Country: United States

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MEDLINETA: Org Lett

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