First total synthesis of protoapigenone and its analogues as potent cytotoxic agents.

First total synthesis of protoapigenone and its analogues as potent cytotoxic agents. Research Abstract Details 

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First total synthesis of protoapigenone and its analogues as potent cytotoxic agents. Abstract Text:

An-Shen Lin,Kyoko Nakagawa-Goto,Fang-Rong Chang,Donglei Yu,Susan L Morris-Natschke,Chin-Chung Wu,Shu-Li Chen,Yang-Chang Wu,Kuo-Hsiung Lee,

Protoapigenone (1), isolated from Thelypteris torresiana, previously showed significant cytotoxic activity against five human cancer cell lines. In a continued structure-activity relationship study, the first total synthesis and modification of 1 were achieved. All synthesized compounds and related intermediates were evaluated for cytotoxic activity against five human cancer cell lines, HepG2, Hep3B, MDA-MB-231, MCF-7, and A549. Among them, 24 showed 2.2-14.2-fold greater cytotoxicity than 1 and naphthyl A-ring analogues remarkably enhanced the activity.

First total synthesis of protoapigenone and its analogues as potent cytotoxic agents. Publishing Authors By Initials

AS Lin,K Nakagawa-Goto,FR Chang,D Yu,SL Morris-Natschke,CC Wu,SL Chen,YC Wu,KH Lee,

For similar biochemical phenomena, metabolism, and nutrition: biochemical phenomena: structure-activity relationship research abstracts see: biochemical phenomena, metabolism, and nutrition: biochemical phenomena: structure-activity relationship research

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MEDLINE DATE:

First total synthesis of protoapigenone and its analogues as potent cytotoxic agents. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of medicinal chemistry

VOLUME: 50

Page Numbers: 3921-7

Journal Abbreviation: J. Med. Chem.

ISSN: 0022-2623

DAY: 10

MONTH: 07

YEAR: 2007

First total synthesis of protoapigenone and its analogues as potent cytotoxic agents. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9716531

First total synthesis of protoapigenone and its analogues as potent cytotoxic agents. Keywords Mesh Terms:

KEYWORDS: Structure-Activity Relationship

MESH TERMS: pharmacology

Chemical & Substance for Abstract: First total synthesis of protoapigenone and its analogues as potent cytotoxic agents. Information

Substance Name: protoapigenone

Registry Number: 0

Grant and Affiliation Information for First total synthesis of protoapigenone and its analogues as potent cytotoxic agents.

AFFILIATION: Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan.

Country: United States

AGENCY: United States NCI

GRANT: CA 17625

ACRONYM: CA

MEDLINETA: J Med Chem

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