Fine-mapping and comprehensive transcript analysis reveals nonsynonymous variants within a novel 1.17 Mb blood pressure QTL region on rat chromosome 10.

Fine-mapping and comprehensive transcript analysis reveals nonsynonymous variants within a novel 1.17 Mb blood pressure QTL region on rat chromosome 10. Research Abstract Details 

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Fine-mapping and comprehensive transcript analysis reveals nonsynonymous variants within a novel 1.17 Mb blood pressure QTL region on rat chromosome 10. Abstract Text:

Yasser Saad,Michael R Garrett,Ezhilarasi Manickavasagam,Shane Yerga-Woolwine,Phyllis Farms,Tracy Radecki,Bina Joe,

The presence of blood pressure (BP) quantitative trait loci (QTL) on rat chromosome 10 has been clearly demonstrated by linkage analysis and substitution mapping. Using congenic strains containing the LEW rat chromosomal segments on the Dahl salt-sensitive (S) rat background, further iterations of congenic substrains were constructed and characterized to fine-map a chromosome 10 region (QTL1) linked to blood pressure. Comparison of seven congenic substrains refined QTL1 to a 1.17 Mb segment flanked by D10Mco88 and D10Mco89, which are located at 71,513,116 and 72,684,774 bp, respectively. The newly defined QTL1, containing 18 genes, is captured in its entirety within a single congenic substrain. A thorough transcript analysis revealed that 3 of these 18 genes, Ccl5, Ddx52, and RGD1559577, had nonsynonymous allelic variations between the S rat and the LEW rat. None of the detected transcripts within the newly defined QTL1 are implicated directly in BP control in humans or model organisms. Therefore, the present work defines a novel blood pressure QTL with three potential quantitative trait nucleotides.

Fine-mapping and comprehensive transcript analysis reveals nonsynonymous variants within a novel 1.17 Mb blood pressure QTL region on rat chromosome 10. Publishing Authors By Initials

Y Saad,MR Garrett,E Manickavasagam,S Yerga-Woolwine,P Farms,T Radecki,B Joe,

For similar genetic phenomena: variation (genetics) research abstracts see: genetic phenomena: variation (genetics) research

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Fine-mapping and comprehensive transcript analysis reveals nonsynonymous variants within a novel 1.17 Mb blood pressure QTL region on rat chromosome 10. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Genomics

VOLUME: 89

Page Numbers: 343-53

Journal Abbreviation: Genomics

ISSN: 0888-7543

DAY: 10

MONTH: 01

YEAR: 2007

Fine-mapping and comprehensive transcript analysis reveals nonsynonymous variants within a novel 1.17 Mb blood pressure QTL region on rat chromosome 10. Information

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LANGUAGE: eng

NlmUniqueID: 8800135

Fine-mapping and comprehensive transcript analysis reveals nonsynonymous variants within a novel 1.17 Mb blood pressure QTL region on rat chromosome 10. Keywords Mesh Terms:

KEYWORDS: Variation (Genetics)

MESH TERMS: genetics

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Grant and Affiliation Information for Fine-mapping and comprehensive transcript analysis reveals nonsynonymous variants within a novel 1.17 Mb blood pressure QTL region on rat chromosome 10.

AFFILIATION: Department of Physiology, Pharmacology, Metabolism, and Cardiovascular Sciences, University of Toledo, Health Science Campus, 3035 Arlington Avenue, Toledo, OH 43614-5804, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: R01 HL020176-29

ACRONYM: HL

MEDLINETA: Genomics

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