Finding the genes underlying adaptation to hypoxia using genomic scans for genetic adaptation and admixture mapping.

Finding the genes underlying adaptation to hypoxia using genomic scans for genetic adaptation and admixture mapping. Research Abstract Details 

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Finding the genes underlying adaptation to hypoxia using genomic scans for genetic adaptation and admixture mapping. Abstract Text:

Mark D Shriver,Rui Mei,Abigail Bigham,Xianyun Mao,Tom D Brutsaert,Esteban J Parra,Lorna G Moore,

The complete sequencing the human genome and recent analytical advances have provided the opportunity to perform genome-wide studies of human variation. There is substantial potential for such population-genomic approaches to assist efforts to uncover the historical and demographic histories of human populations. Additionally, these genome-wide datasets allow for investigations of variability among genomic regions. Although all genomic regions in a population have experienced the same demographic events, they have not been affected by these events in precisely the same way. Much of the variability among genomic regions is simply the result of genetic drift (i.e., gene frequency changes resulting from the effects of small breeding-population size), but some is also the result of genetic adaptation, which will only affect the gene under selection and nearby regions. We have used a new DNA typing assay that allows for the genotyping of thousands of SNPs on hundreds of samples to identify regions most likely to have been affected by genetic adaptation. Populations that have inhabited different niches (e.g., high-altitude regions) can be used to identify genes underlying the physiological differences. We have used two methods (admixture mapping and genome scans for genetic adaptation) founded on the population-genomic paradigms to search for genes underlying population differences in response to chronic hypoxia. There is great promise that together these methods will facilitate the discovery of genes influencing hypoxic response.

Finding the genes underlying adaptation to hypoxia using genomic scans for genetic adaptation and admixture mapping. Publishing Authors By Initials

MD Shriver,R Mei,A Bigham,X Mao,TD Brutsaert,EJ Parra,LG Moore,

For similar genetic phenomena: variation (genetics) research abstracts see: genetic phenomena: variation (genetics) research

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Finding the genes underlying adaptation to hypoxia using genomic scans for genetic adaptation and admixture mapping. Journal Published:

PUBLICATION TYPE: Review

Journal: Advances in experimental medicine and biology

VOLUME: 588

Page Numbers: 89-100

Journal Abbreviation: Adv. Exp. Med. Biol.

ISSN: 0065-2598

DAY: 3

MONTH: 12

YEAR: 2006

Finding the genes underlying adaptation to hypoxia using genomic scans for genetic adaptation and admixture mapping. Information

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LANGUAGE: eng

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Finding the genes underlying adaptation to hypoxia using genomic scans for genetic adaptation and admixture mapping. Keywords Mesh Terms:

KEYWORDS: Variation (Genetics)

MESH TERMS: metabolism

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Substance Name: DNA

Registry Number: 9007-49-2

Grant and Affiliation Information for Finding the genes underlying adaptation to hypoxia using genomic scans for genetic adaptation and admixture mapping.

AFFILIATION: Department of Anthropology, Penn State University, University Park, PA 16802, USA. mds17@psu.edu

Country: United States

AGENCY: United States FIC

GRANT: TW 01188

ACRONYM: TW

MEDLINETA: Adv Exp Med Biol

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