Filiasparosides A-D, cytotoxic steroidal saponins from the roots of Asparagus filicinus.

Filiasparosides A-D, cytotoxic steroidal saponins from the roots of Asparagus filicinus. Research Abstract Details 

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Filiasparosides A-D, cytotoxic steroidal saponins from the roots of Asparagus filicinus. Abstract Text:

Li-Bo Zhou,Tzu-Hsuan Chen,Kenneth F Bastow,Makio Shibano,Kuo-Hsiung Lee,Dao-Feng Chen,

Four new steroidal saponins, filiasparosides A-D (1-4), together with known aspafiliosides A (5) and B (6) were isolated from the roots of Asparagus filicinus. The structures of these new compounds were elucidated by detailed spectroscopic study and chemical analysis. Compounds 1-6 were cytotoxic against human lung carcinoma (A549) and breast adenocarcinoma (MCF-7) tumor cell lines with EC(50) values of 2.3-16.8 microg/mL. Compound 3 showed the most potent cytotoxicity, with EC(50) values of 2.3 and 3.0 microg/mL toward A549 and MCF-7 cell lines, respectively.

Filiasparosides A-D, cytotoxic steroidal saponins from the roots of Asparagus filicinus. Publishing Authors By Initials

LB Zhou,TH Chen,KF Bastow,M Shibano,KH Lee,DF Chen,

For similar polycyclic compounds: steroids research abstracts see: polycyclic compounds: steroids research

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Filiasparosides A-D, cytotoxic steroidal saponins from the roots of Asparagus filicinus. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of natural products

VOLUME: 70

Page Numbers: 1263-7

Journal Abbreviation: J. Nat. Prod.

ISSN: 0163-3864

DAY: 13

MONTH: 07

YEAR: 2007

Filiasparosides A-D, cytotoxic steroidal saponins from the roots of Asparagus filicinus. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7906882

Filiasparosides A-D, cytotoxic steroidal saponins from the roots of Asparagus filicinus. Keywords Mesh Terms:

KEYWORDS: Steroids

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Filiasparosides A-D, cytotoxic steroidal saponins from the roots of Asparagus filicinus. Information

Substance Name: Steroids

Registry Number: 0

Grant and Affiliation Information for Filiasparosides A-D, cytotoxic steroidal saponins from the roots of Asparagus filicinus.

AFFILIATION: Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai 200032, People's Republic of China.

Country: United States

AGENCY: United States NCI

GRANT: CA-17625

ACRONYM: CA

MEDLINETA: J Nat Prod

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