Figurate and bullous eruption in association with breast carcinoma.

Figurate and bullous eruption in association with breast carcinoma. Research Abstract Details 

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Figurate and bullous eruption in association with breast carcinoma. Abstract Text:

We describe a patient with two coexistent cutaneous eruptions: (1) trauma-induced bullae of the distal extremities and elbows and (2) multiple concentric gyrate lesions on the trunk and extremities, some of which became bullous. The gyrate lesions were stationary and nonpruritic. Biopsy of both types of lesions showed a subepidermal blister and a minimal inflammatory infiltrate. Direct immunofluorescence revealed linear deposition of IgG and C3 at the dermoepidermal junction and indirect immunofluorescence was negative. By immunoelectron microscopy, these immune deposits were localized to the lower lamina lucida. The eruption was not controlled despite high-dose (80 mg/d) oral administration of prednisone and required the addition of an oral administration of methotrexate (20 mg weekly). On further evaluation, an intraductal mammary carcinoma was detected. Following radiation therapy, the methotrexate and prednisone therapy were tapered without recurrence of the eruption during a follow-up period of 18 months.

Figurate and bullous eruption in association with breast carcinoma. Publishing Authors By Initials

For similar skin and connective tissue diseases: skin diseases: skin diseases, vesiculobullous research abstracts see: skin and connective tissue diseases: skin diseases: skin diseases, vesiculobullous research

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Figurate and bullous eruption in association with breast carcinoma. Journal Published:

PUBLICATION TYPE: Review

Journal: Archives of dermatology

VOLUME: 126

Page Numbers: 649-52

Journal Abbreviation: Arch Dermatol

ISSN: 0003-987X

DAY: 17

MONTH: May

YEAR: 1990

Figurate and bullous eruption in association with breast carcinoma. Information

Number of References: 16

LANGUAGE: eng

NlmUniqueID: 372433

Figurate and bullous eruption in association with breast carcinoma. Keywords Mesh Terms:

KEYWORDS: Skin Diseases, Vesiculobullous

MESH TERMS: pathology

Chemical & Substance for Abstract: Figurate and bullous eruption in association with breast carcinoma. Information

Substance Name: Methotrexate

Registry Number: 59-05-2

Grant and Affiliation Information for Figurate and bullous eruption in association with breast carcinoma.

AFFILIATION: Department of Dermatology, Yale University School of Medicine, New Haven, Conn. 06510.

Country: UNITED STATES

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MEDLINETA: Arch Dermatol

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