Field stimulation of cells in suspension: use of a hybrid finite element method.

Field stimulation of cells in suspension: use of a hybrid finite element method. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Field stimulation of cells in suspension: use of a hybrid finite element method. Abstract Text:

Wenjun Ying,N Pourtaheri,C S Henriquez,Wenjun Ying,Navid Pourtaheri,Craig S Henriquez,

Electric fields are used in a range of applications, including gene transfection, electrochemotherapy of tumors and cardiac defibrillation. Despite the widespread use of electric fields, most of the theoretical and computational studies on discrete cellular tissue have focused on a single cell. In this work, we propose a hybrid finite element method to simulate the effects of external electric fields on clusters of excitable cells. The method can be used to model cells of arbitrary cell geometries and non-linear membrane dynamics. The results show that the response of multiple cell, like a single cell, is a two-stage process consisting of the initial polarization that proceeds with cellular time constant (less than one microsecond) and the actual excitation of the cell membrane that proceeds with the membrane time constant (on the order of milliseconds). The results also show that the stimulation of a given cell depends in part on the arrangement of cells within the field and not simply the location within the field, suggesting that classical approaches that ignores the effect of the cells on the field do not adequately predict the cellular response.

Field stimulation of cells in suspension: use of a hybrid finite element method. Publishing Authors By Initials

W Ying,N Pourtaheri,CS Henriquez,W Ying,N Pourtaheri,CS Henriquez,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Field stimulation of cells in suspension: use of a hybrid finite element method. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Conference proceedings : ... Annual International

VOLUME: 1

Page Numbers: 2276-9

Journal Abbreviation:

ISSN: 1557-170X

DAY: 23

MONTH: 10

YEAR: 2006

Field stimulation of cells in suspension: use of a hybrid finite element method. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101243413

Field stimulation of cells in suspension: use of a hybrid finite element method. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Field stimulation of cells in suspension: use of a hybrid finite element method. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Field stimulation of cells in suspension: use of a hybrid finite element method.

AFFILIATION: Dept. of Biomed. Eng., Duke Univ., Durham, NC.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Conf Proc IEEE Eng Med Biol So

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Field stimulation of cells in suspension: use of a hybrid finite element method Related Publications

• Detection of the 35delG/GJB2 and del(GJB6-D13S1830) Mutations in Venezuelan Patients with Autosomal Recessive Nonsyndromic Hearing Loss.
• Effect of gap junction distribution on impulse propagation in a monolayer of myocytes: a model study.
• Effect of nonuniform interstitial space properties on impulse propagation: a discrete multidomain model.
• Field stimulation of cells in suspension: use of a hybrid finite element method.
• Loading effect of fibroblast-myocyte coupling on resting potential, impulse propagation, and repolarization: insights from a microstructure model.
• Low comorbidity and male sex in nonagenarian community-dwelling people are associated with better functional and cognitive abilities: the NonaSantfeliu study.
• Modelling cardiac fibroblasts: interactions with myocytes and their impact on impulse propagation.
• Surgical treatment of nephritis.
• Treatment of chronic anal fissure by gonyautoxin.
• [IMMUNOPATHOLOGICAL STUDIES ON HARDER'S GLAND IN RATS.]
• [Impression technic for peripheral crowns. Splints and multiple fixed prosthesis. Personal technic]
• [Not Available.]
• [Not Available.]
• [On microcicatrices in human epithelial bodies.]