Fibronectin enhances healing of excised wounds in rats.

Fibronectin enhances healing of excised wounds in rats. Research Abstract Details 

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Fibronectin enhances healing of excised wounds in rats. Abstract Text:

Fibronectin (Fn) is a normal plasma and extracellular matrix glycoprotein that is involved in each phase of wound healing. For example, it is incorporated into both fibrin and collagen fibers; it opsonizes circulating tissue debris for removal by the reticuloendothelial system; it is used by macrophages, fibroblasts, and epithelial cells to move into the wound; and fragments of Fn are chemotactic for fibroblasts. In this study, experiments with rats showed that excised lesions treated with Fn healed more rapidly than paired control lesions treated with the carrier alone. Applications of Fn once a day for two days were as effective in speeding healing as twice-daily applications of Fn for 12 days. A single treatment with Fn soon after the initial injury was nearly as effective as more prolonged treatment regimens.

Fibronectin enhances healing of excised wounds in rats. Publishing Authors By Initials

For similar biological phenomena, cell phenomena, and immunity: biological phenomena: regeneration: wound healing research abstracts see: biological phenomena, cell phenomena, and immunity: biological phenomena: regeneration: wound healing research

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Fibronectin enhances healing of excised wounds in rats. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Archives of dermatology

VOLUME: 124

Page Numbers: 221-5

Journal Abbreviation: Arch Dermatol

ISSN: 0003-987X

DAY: 17

MONTH: Feb

YEAR: 1988

Fibronectin enhances healing of excised wounds in rats. Information

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LANGUAGE: eng

NlmUniqueID: 372433

Fibronectin enhances healing of excised wounds in rats. Keywords Mesh Terms:

KEYWORDS: Wound Healing

MESH TERMS: drug effects

Chemical & Substance for Abstract: Fibronectin enhances healing of excised wounds in rats. Information

Substance Name: Dimethyl Sulfoxide

Registry Number: 67-68-5

Grant and Affiliation Information for Fibronectin enhances healing of excised wounds in rats.

AFFILIATION: Department of Cell and Molecular Biology, Medical College of Georgia, Augusta 30912.

Country: UNITED STATES

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MEDLINETA: Arch Dermatol

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