Fibroblast growth factor causes an early increase in phosphorylation of a membrane protein in quiescent 3T3 cells.

Fibroblast growth factor causes an early increase in phosphorylation of a membrane protein in quiescent 3T3 cells. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Fibroblast growth factor causes an early increase in phosphorylation of a membrane protein in quiescent 3T3 cells. Abstract Text:

M Nilsen-Hamilton,R T Hamilton,

THE regulatory systems controlling cell division have not been identified, but it has been shown that growth factors such as epidermal growth factor, fibroblast growth factor (FGF), and serum initiate rapid changes in cellular metabolism, probably involving post-transcriptional control mechanisms(1-5). As phosphorylation has been shown to be an important regulatory mechanism in several metabolic pathways, we initiated experiments to determine whether factors which stimulate DNA synthesis also stimulate endogenous phosphorylation. We find mat, within 5 min of addition of FGF or serum to (32)P-labelled Swiss 3T3 cells, there is a specific increase in the phosphorylation of a membrane protein with an apparent molecular weight of 33,000. Experiments with isolated cell fractions demonstrate that the phosphorylation of this protein is stimulated by cyclic AMP. This rapid and specific response to mitogens raises the possibility that this phosphorylation might be part of the initial, cellular signal for DNA synthesis.

Fibroblast growth factor causes an early increase in phosphorylation of a membrane protein in quiescent 3T3 cells. Publishing Authors By Initials

M Nilsen-Hamilton,RT Hamilton,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Fibroblast growth factor causes an early increase in phosphorylation of a membrane protein in quiescent 3T3 cells. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Nature

VOLUME: 279

Page Numbers: 444-6

Journal Abbreviation: Nature

ISSN: 0028-0836

DAY: 31

MONTH: May

YEAR: 1979

Fibroblast growth factor causes an early increase in phosphorylation of a membrane protein in quiescent 3T3 cells. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 410462

Fibroblast growth factor causes an early increase in phosphorylation of a membrane protein in quiescent 3T3 cells. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Fibroblast growth factor causes an early increase in phosphorylation of a membrane protein in quiescent 3T3 cells. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Fibroblast growth factor causes an early increase in phosphorylation of a membrane protein in quiescent 3T3 cells.

AFFILIATION:

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Nature

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Fibroblast growth factor causes an early increase in phosphorylation of a membrane protein in quiescent 3T3 cells Related Publications

• 'Physical Inactivity' (Low NEAT) is NOT the Same Physiologically as the 'Lack of Exercise'?: 342: 1:05 PM -1:15 PM.
• Analysis of association between the serotonin transporter and antidepressant response in a large clinical sample.
• Are Chemical (Lipase Dependent) Signals Sufficient to Mimic Exercise-Induced Endothelial Phenotypes?: 67: 1:35 PM-2:00 PM.
• Arsenic disruption of steroid receptor gene activation: Complex dose-response effects are shared by several steroid receptors.
• Associations of Ki-ras proto-oncogene mutation and p53 gene overexpression in sporadic colorectal adenomas with demographic and clinicopathologic characteristics.
• Automated Quantification of Lymph Node Size and Number in Surgical Specimens of Stage II Colorectal Cancer.
• Developing clinical standards and accrediting clinics in infertility care.
• Diphenylindane-based proteomimetics reproduce the projection of the i, i+3, i+4, and i+7 residues on an alpha-helix.
• Effects of eccentric contractions on skeletal muscle function in a malignant hyperthermia mouse model: 2352: board #31 june 1 2:00 PM -3:30 PM.
• Fibroblast growth factor causes an early increase in phosphorylation of a membrane protein in quiescent 3T3 cells.
• Gene-lifecourse interaction for alcohol consumption in adolescence and young adulthood: five monoamine genes.
• Helix mimetics as inhibitors of the interaction of the estrogen receptor with coactivator peptides.
• Identification of atherosclerotic lipid deposits by diffusion-weighted imaging.
• Identification of cysteines involved in S-nitrosylation, S-glutathionylation, and oxidation to disulfides in ryanodine receptor type 1.
• Introduction and Overview: 341: 1:00 PM-1:05 PM.
• Introduction and Overview: 65: 1:00 PM-1:10 PM.
• Modifications of the GSK3beta substrate sequence to produce substrate-mimetic inhibitors of Akt as potential anti-cancer therapeutics.
• Nonlinear surface waves in soft, weakly compressible elastic media.
• Prize-based contingency management does not increase gambling.
• Protein-protein interaction inhibitors: small molecules from screening techniques.
• Recognition of solvent exposed protein surfaces using anthracene derived receptors.
• Shifts in thioredoxin reductase activity and oxidant status in mononuclear cells obtained from transition dairy cattle.
• Signaling in lipopolysaccharide-induced stabilization of formyl peptide receptor 1 mRNA in mouse peritoneal macrophages.
• Sociology-the poor relation in alcohol and drug research?
• Sonotubometry.
• Structure-activity studies on a library of potent calix[4]arene-based PDGF antagonists that inhibit PDGF-stimulated PDGFR tyrosine phosphorylation.
• Synthesis and evaluation of potent, highly-selective, 3-aryl-piperazinone inhibitors of protein geranylgeranyltransferase-I.
• Synthetic non-peptide mimetics of alpha-helices.
• Two lyophilized polymer matrix recombinant human bone morphogenetic protein-2 carriers in rabbit calvarial defects.
• Zfp423 controls proliferation and differentiation of neural precursors in cerebellar vermis formation.