Fibroblast contraction of collagen matrices with and without covalently bound hyaluronan.

Fibroblast contraction of collagen matrices with and without covalently bound hyaluronan. Research Abstract Details 

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Fibroblast contraction of collagen matrices with and without covalently bound hyaluronan. Abstract Text:

L L Huang-Lee,M E Nimni,

Hyaluronan, which is found in high concentrations in fetal tissues, has been suggested to play a major role in preventing scar formation in fetal wounds. We have developed a floating collagen fibrillar matrix (CFM) made out of reconstituted type I collagen for the purpose of evaluating the ability of hyaluronan to inhibit the fibroblast induced contraction of the matrix. When hyaluronan is covalently bound to collagen it appears to better support fibroblast proliferation and matrices are less contractible by these cells than when hyaluronan interacts only ionically. When hyaluronan is bridged between collagen fibrils by a network of extensive covalent crosslinks, contractibility by fibroblasts is abolished. These modified collagen matrices may prove to be very useful in the development of bioprostheses and implants.

Fibroblast contraction of collagen matrices with and without covalently bound hyaluronan. Publishing Authors By Initials

LL Huang-Lee,ME Nimni,

For similar digestive, oral, and skin physiology: skin physiology research abstracts see: digestive, oral, and skin physiology: skin physiology research

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Fibroblast contraction of collagen matrices with and without covalently bound hyaluronan. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of biomaterials science. Polymer edition

VOLUME: 5

Page Numbers: 99-109

Journal Abbreviation:

ISSN: 0920-5063

DAY: 20

MONTH: 02

YEAR: 1993

Fibroblast contraction of collagen matrices with and without covalently bound hyaluronan. Information

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LANGUAGE: eng

NlmUniqueID: 9007393

Fibroblast contraction of collagen matrices with and without covalently bound hyaluronan. Keywords Mesh Terms:

KEYWORDS: Skin Physiology

MESH TERMS: analysis

Chemical & Substance for Abstract: Fibroblast contraction of collagen matrices with and without covalently bound hyaluronan. Information

Substance Name: DNA

Registry Number: 9007-49-2

Grant and Affiliation Information for Fibroblast contraction of collagen matrices with and without covalently bound hyaluronan.

AFFILIATION: Department of Biochemistry, School of Medicine, University of Southern California, Los Angeles.

Country: NETHERLANDS

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MEDLINETA: J Biomater Sci Polym Ed

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