Fibrin- and fibrinogen-related antigens in patients with venous disease and venous ulceration.

Fibrin- and fibrinogen-related antigens in patients with venous disease and venous ulceration. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Fibrin- and fibrinogen-related antigens in patients with venous disease and venous ulceration. Abstract Text:

Abnormalities in systemic fibrinolysis have been implicated in the pathogenesis of venous ulceration. Patients with venous disease have a prolonged euglobulin lysis time and elevated plasma fibrinogen levels, yet little is known about the metabolism of fibrinogen and fibrin in such patients. In this study, we have used a technique that involves electrophoresis and densitometric analysis of captured fibrin-related antigens to measure the concentration and proportions of the individual fibrin and fibrinogen degradation products in patients with venous disease of the lower extremity. As a group, patients with venous disease had markedly elevated levels of total fibrin-related antigen and D-dimer, the terminal degradation product of cross-linked fibrin. Levels of D-monomer, the breakdown product of fibrinogen and non-cross-linked fibrin monomer, and a measure of fibrinogenolysis were normal in all patients. In patients with ulcers, the levels of D-dimer were disproportionately higher than expected from fibrin monomer levels. On an individual basis, significant elevations of D-dimer were present in six (55%) of the 11 patients with venous disease with ulcers and in three (43%) of the seven patients with venous disease without ulcers. We conclude that patients with venous disease have uniform evidence for enhanced fibrin formation, as evidenced by elevated levels of total fibrin-related antigen and D-dimer. This is regardless of whether the venous disease is accompanied by ulceration.

Fibrin- and fibrinogen-related antigens in patients with venous disease and venous ulceration. Publishing Authors By Initials

For similar cardiovascular diseases: vascular diseases: varicose veins research abstracts see: cardiovascular diseases: vascular diseases: varicose veins research

PUBMED ID PMID:

MEDLINE DATE:

Fibrin- and fibrinogen-related antigens in patients with venous disease and venous ulceration. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Archives of dermatology

VOLUME: 127

Page Numbers: 75-8

Journal Abbreviation: Arch Dermatol

ISSN: 0003-987X

DAY: 17

MONTH: Jan

YEAR: 1991

Fibrin- and fibrinogen-related antigens in patients with venous disease and venous ulceration. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 372433

Fibrin- and fibrinogen-related antigens in patients with venous disease and venous ulceration. Keywords Mesh Terms:

KEYWORDS: Varicose Veins

MESH TERMS: pathology

Chemical & Substance for Abstract: Fibrin- and fibrinogen-related antigens in patients with venous disease and venous ulceration. Information

Substance Name: fibrinogen-related antigen

Registry Number: 0

Grant and Affiliation Information for Fibrin- and fibrinogen-related antigens in patients with venous disease and venous ulceration.

AFFILIATION: Department of Dermatology and Cutaneous Surgery, University of Miami School of Medicine, FL 33101.

Country: UNITED STATES

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Arch Dermatol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Fibrin- and fibrinogen-related antigens in patients with venous disease and venous ulceration Related Publications

• A comparison of HRT II and GDx imaging for glaucoma detection in a primary care eye clinic setting.
• Alveolar airspace and pulmonary artery involvement by extramedullary hematopoiesis: a unique manifestation of myelofibrosis.
• Association between obesity and patient satisfaction.
• Can prepared responses be stored subcortically?
• Diabetic maculopathy.
• Disparities in preventive procedures: comparisons of self-report and Medicare claims data.
• Glaucoma and mortality.
• How good are we at diagnosing polycystic ovary syndrome?
• Injectable fillers in aesthetic medicine.
• Is proprioception calibrated during visually guided movements?
• Massive dilatation of the left auricle.
• Muscling in on the genetics of quantitative disease traits.
• Nail dystrophy due to plastic undercoat for holding nail lacquers.
• Post partum discharge against medical advice: who leaves and does it matter?
• Provision of eye care: commissioning change.
• Reaction time differences in spatially constrained bilateral and unilateral movements.
• Sensorimotor adaptation in response to proprioceptive bias.
• Spatially precise bilateral arm movements are controlled by the contralateral hemisphere: evidence from a lateralized visual stimulus paradigm.
• Spectrum of precursor and invasive neoplastic lesions in type 1 congenital pulmonary airway malformation: case report and review of the literature.
• Startle produces early response latencies that are distinct from stimulus intensity effects.
• Startle response is dishabituated during a reaction time task.
• Stuttering priapism associated with hereditary spherocytosis.
• Teaching with evaluation in ants.
• The burden of chronic wounds in the UK.
• The effect of target size and inertial load on the control of rapid aiming movements. A test of speed-sensitive and speed-insensitive strategies.
• The effects of changing movement velocity and complexity on response preparation: evidence from latency, kinematic, and EMG measures.
• The incidence of carcinoma of prostate: an epidemiological survey.
• The influence of advance information on the response complexity effect in manual aiming movements.
• The neuroprotective effects of xenon and helium in an in vitro model of traumatic brain injury.
• The venous leg ulcer quality of life (VLU-QoL) questionnaire: development and psychometric validation.