Fibre type-specific increase in passive muscle tension in spinal cord-injured subjects with spasticity.

Fibre type-specific increase in passive muscle tension in spinal cord-injured subjects with spasticity. Research Abstract Details 

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Fibre type-specific increase in passive muscle tension in spinal cord-injured subjects with spasticity. Abstract Text:

M Charlotte Olsson,Martina ,Lars-Henrik Meyer,Lena Ahnlund,Lennart Gransberg,Wolfgang A Linke,Lars Larsson,

Patients with spasticity typically present with an increased muscle tone that is at least partly caused by an exaggerated stretch reflex. However, intrinsic changes in the skeletal muscles, such as altered mechanical properties of the extracellular matrix or the cytoskeleton, have been reported in response to spasticity and could contribute to hypertonia, although the underlying mechanisms are poorly understood. Here we examined the vastus lateralis muscles from spinal cord-injured patients with spasticity (n = 7) for their passive mechanical properties at three different levels of structural organization, in comparison to healthy controls (n = 7). We also assessed spasticity-related alterations in muscle protein expression and muscle ultrastructure. At the whole-muscle level in vivo, we observed increased passive tension (PT) in some spasticity patients particularly at long muscle lengths, unrelated to stretch reflex activation. At the single-fibre level, elevated PT was found in cells expressing fast myosin heavy chain (MyHC) isoforms, especially MyHC-IIx, but not in those expressing slow MyHC. Type IIx fibres were present in higher than normal proportions in spastic muscles, whereas type I fibres were proportionately reduced. At the level of the isolated myofibril, however, there were no differences in PT between patients and controls. The molecular size of the giant protein titin, a main contributor to PT, was unchanged in spasticity, as was the titin : MyHC ratio and the relative desmin content. Electron microscopy revealed extensive ultrastructural changes in spastic muscles, especially expanded connective tissue, but also decreased mitochondrial volume fraction and appearance of intracellular amorphous material. Results strongly suggest that the global passive muscle stiffening in spasticity patients is caused to some degree by elevated PT of the skeletal muscles themselves. We conclude that this increased PT component arises not only from extracellular matrix remodelling, but also from structural and functional adaptations inside the muscle cells, which alter their passive mechanical properties in response to spasticity in a fibre type-dependent manner.

Fibre type-specific increase in passive muscle tension in spinal cord-injured subjects with spasticity. Publishing Authors By Initials

MC Olsson,M ,LH Meyer,L Ahnlund,L Gransberg,WA Linke,L Larsson,

For similar body regions: extremities: lower extremity: thigh research abstracts see: body regions: extremities: lower extremity: thigh research

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Fibre type-specific increase in passive muscle tension in spinal cord-injured subjects with spasticity. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of physiology

VOLUME: 577

Page Numbers: 339-52

Journal Abbreviation: J. Physiol. (Lond.)

ISSN: 0022-3751

DAY: 24

MONTH: 08

YEAR: 2006

Fibre type-specific increase in passive muscle tension in spinal cord-injured subjects with spasticity. Information

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LANGUAGE: eng

NlmUniqueID: 266262

Fibre type-specific increase in passive muscle tension in spinal cord-injured subjects with spasticity. Keywords Mesh Terms:

KEYWORDS: Thigh

MESH TERMS: physiopathology

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Grant and Affiliation Information for Fibre type-specific increase in passive muscle tension in spinal cord-injured subjects with spasticity.

AFFILIATION: Uppsala University, Department of Neuroscience, Clinical Neurophysiology, 75185 Uppsala, Sweden.

Country: England

AGENCY: United States NIAMS

GRANT: AR47318

ACRONYM: AR

MEDLINETA: J Physiol

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