Fiber density of electrospun gelatin scaffolds regulates morphogenesis of dermal-epidermal skin substitutes.

Fiber density of electrospun gelatin scaffolds regulates morphogenesis of dermal-epidermal skin substitutes. Research Abstract Details 

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Fiber density of electrospun gelatin scaffolds regulates morphogenesis of dermal-epidermal skin substitutes. Abstract Text:

H M Powell,S T Boyce,

Porous, nowoven fibrous gelatin scaffolds were prepared using electrospinning. Electrospun scaffolds with varying fiber diameter, interfiber distance, and porosity were fabricated by altering the concentration of the electrospinning solution. Solution concentration was a significant predictor of fiber diameter, interfiber distance, and porosity with higher solution concentration correlated with larger fiber diameters and interfiber distances. The potential of electrospun gelatin as a scaffolding material for dermal and epidermal tissue regeneration was also evaluated. Interfiber distances >5.5 microm allowed deeper penetration of human dermal fibroblasts into the scaffold, whereas cells in scaffolds with more densely packed fibers were able to infiltrate only into the upper regions. Scaffolds with interfiber distances

Fiber density of electrospun gelatin scaffolds regulates morphogenesis of dermal-epidermal skin substitutes. Publishing Authors By Initials

HM Powell,ST Boyce,

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Fiber density of electrospun gelatin scaffolds regulates morphogenesis of dermal-epidermal skin substitutes. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of biomedical materials research. Part A

VOLUME: 84

Page Numbers: 1078-86

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ISSN: 1552-4965

DAY: 15

MONTH: Mar

YEAR: 2008

Fiber density of electrospun gelatin scaffolds regulates morphogenesis of dermal-epidermal skin substitutes. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Fiber density of electrospun gelatin scaffolds regulates morphogenesis of dermal-epidermal skin substitutes.

AFFILIATION: Research Department, Shriners Burns Hospital, 3229 Burnet Ave., Cincinnati, Ohio 45229, USA. hpowell@shrinenet.org

Country: United States

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MEDLINETA: J Biomed Mater Res A

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