[Fiber as a carcinogenic agent]

[Fiber as a carcinogenic agent] Research Abstract Details 

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[Fiber as a carcinogenic agent] Abstract Text:

According to the findings that long, thin, and durable fibres have a high carcinogenic potency after intrapleural and intraperitoneal administration, the elongated shape of a particle represents a carcinogenic agent; this physical phenomenon is a special cause of cancer. It induces a biological process which can lead to cancer by several as yet unknown steps. However, the properties of the material the fibres are made of determine the carcinogenic potency of a fibre in a secondary way although they do not seem to be responsible for the true carcinogenic agent. For example, these properties determine the degree of solubility and flexibility. The persistence of fibres in the tissue is a very important property with regard to their carcinogenic effect because the formation of a tumour takes many years or some decades. It can be assumed that a fibre has to remain by the bronchial or serosa tissue until the induction of tumour cells occurs. If this hypothesis is correct, there could be a "durability threshold value" for fibres whose length and diameter would otherwise indicate a high carcinogenic potency. There are indications that other fibre properties apart from length, diameter and durability are important for tumour induction, however, at present, they cannot be included in a definition of carcinogenic fibres. It is proposed to classify all natural and man-made mineral fibres with an aspect ratio of greater than 5:1 as carcinogenic when they are longer than 3 microns, thinner than 1 micron (or can split into such fine fibres) and when they can persist in the tissue for more than 3 years.

[Fiber as a carcinogenic agent] Publishing Authors By Initials

For similar neoplasms research abstracts see: neoplasms research

PUBMED ID PMID:

MEDLINE DATE:

[Fiber as a carcinogenic agent] Journal Published:

PUBLICATION TYPE: Review

Journal: Zentralblatt für Bakteriologie, Mikrobiologie und

VOLUME: 184

Page Numbers: 1-23

Journal Abbreviation:

ISSN: 0932-6073

DAY: 26

MONTH: Apr

YEAR: 1987

[Fiber as a carcinogenic agent] Information

Number of References: 66

LANGUAGE: ger

NlmUniqueID: 8606774

[Fiber as a carcinogenic agent] Keywords Mesh Terms:

KEYWORDS: Neoplasms

MESH TERMS: etiology

Chemical & Substance for Abstract: [Fiber as a carcinogenic agent] Information

Substance Name: Asbestos

Registry Number: 1332-21-4

Grant and Affiliation Information for [Fiber as a carcinogenic agent]

AFFILIATION:

Country: GERMANY, WEST

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Zentralbl Bakteriol Mikrobiol

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