FGFR3 mutations and a normal CK20 staining pattern define low-grade noninvasive urothelial bladder tumours.

FGFR3 mutations and a normal CK20 staining pattern define low-grade noninvasive urothelial bladder tumours. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

FGFR3 mutations and a normal CK20 staining pattern define low-grade noninvasive urothelial bladder tumours. Abstract Text:

Johanna M M van Oers,Peter J Wild,Maximilian Burger,Stefan Denzinger,Robert Stoehr,Elke Rosskopf,Ferdinand Hofstaedter,Ewout W Steyerberg,Monika Klinkhammer-Schalke,Ellen C Zwarthoff,Theodorus H van der Kwast,Arndt Hartmann,Johanna M M van Oers,Peter J Wild,Maximilian Burger,Stefan Denzinger,Robert Stoehr,Elke Rosskopf,Ferdinand Hofstaedter,Ewout W Steyerberg,Monika Klinkhammer-Schalke,Ellen C Zwarthoff,Theodorus H van der Kwast,Arndt Hartmann,

OBJECTIVES: Molecular markers superior to conventional clinicopathologic parameters are needed to predict disease courses in bladder cancer patients. In this study, we investigated four markers (Ki-67, TP53, CK20, FGFR3) in primary urothelial bladder tumours and compared them with traditional pathologic features. METHODS: Tissue microarrays were used to analyse CK20, TP53, and Ki-67 expression immunohistochemically in 255 unselected patients. FGFR3 mutations were detected by SNaPshot analysis. RESULTS: Abnormal CK20 expression was strongly associated with higher tumour grades and stages (p < 0.001); however, 65% of pTa tumours revealed an abnormal CK20 pattern. In the group of pTaG1 tumours, 59% presented with an abnormal CK20 pattern, whereas 82% carried the FGFR3 mutation. In the group of bladder tumours with normal CK20 pattern, the FGFR3 gene was mutated in 89%, whereas a mutated FGFR3 gene was found in only 37% of cases with abnormal CK20 expression (p < 0.001). All markers proved to be strong predictors of disease-specific survival in univariate studies. However, in multivariate analyses they were not independent from classical pathologic parameters. None of the molecular markers was significantly associated with tumour recurrence. CONCLUSIONS: Dysregulation of CK20 expression is an early event in the carcinogenesis of papillary noninvasive bladder cancer, but occurs later than FGFR3 mutations. The group of low-grade noninvasive papillary tumours is defined by the presence of an FGFR3 mutation and a normal CK20 expression pattern.

FGFR3 mutations and a normal CK20 staining pattern define low-grade noninvasive urothelial bladder tumours. Publishing Authors By Initials

JM van Oers,PJ Wild,M Burger,S Denzinger,R Stoehr,E Rosskopf,F Hofstaedter,EW Steyerberg,M Klinkhammer-Schalke,EC Zwarthoff,TH van der Kwast,A Hartmann,JM van Oers,PJ Wild,M Burger,S Denzinger,R Stoehr,E Rosskopf,F Hofstaedter,EW Steyerberg,M Klinkhammer-Schalke,EC Zwarthoff,TH van der Kwast,A Hartmann,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

FGFR3 mutations and a normal CK20 staining pattern define low-grade noninvasive urothelial bladder tumours. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: European urology

VOLUME: 52

Page Numbers: 760-8

Journal Abbreviation: Eur. Urol.

ISSN: 0302-2838

DAY: 12

MONTH: 01

YEAR: 2007

FGFR3 mutations and a normal CK20 staining pattern define low-grade noninvasive urothelial bladder tumours. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7512719

FGFR3 mutations and a normal CK20 staining pattern define low-grade noninvasive urothelial bladder tumours. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: FGFR3 mutations and a normal CK20 staining pattern define low-grade noninvasive urothelial bladder tumours. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for FGFR3 mutations and a normal CK20 staining pattern define low-grade noninvasive urothelial bladder tumours.

AFFILIATION: Department of Pathology, Erasmus MC, Rotterdam, The Netherlands.

Country: Switzerland

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Eur Urol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

FGFR3 mutations and a normal CK20 staining pattern define low-grade noninvasive urothelial bladder tumours Related Publications

• Acute disseminated histoplasmosis in infancy in Brazil: report of a case and review.
• Afterglows from the largest explosions in the universe.
• Amyloid beta as a regulator of lipid homeostasis.
• Asymptotically distribution-free (ADF) interval estimation of coefficient alpha.
• Bacteraemia in 66 cats and antimicrobial susceptibility of the isolates (1995-2004).
• Correlation between Alcian blue-periodic acid-Schiff stain and immunohistochemical expression of mucin 2 in Barrett's oesophagus.
• Dipeptide metabolism in the isolated perfused rat small intestine.
• Echinodol: A New Cembrene Derivative from Echinodorus grandiflorus.
• Expression of mucin-2 and correlation with PAS-alcian blue stain in Barrett's esophagus.
• FGFR3 mutations and a normal CK20 staining pattern define low-grade noninvasive urothelial bladder tumours.
• Four-dimensional magnetic resonance imaging for the determination of tumour movement and its evaluation using a dynamic porcine lung phantom.
• Hazards for pain severity and pain interference with daily living, with exploration of brief pain inventory cutpoints, among women with metastatic breast cancer.
• Interaural fluctuations and the detection of interaural incoherence. II. Brief duration noises.
• Interaural fluctuations and the detection of interaural incoherence. III. Narrowband experiments and binaural models.
• Interaural fluctuations and the detection of interaural incoherence: bandwidth effects.
• Lateralization of sine tones-interaural time vs phase (L).
• Light-mediated control of quinolizidine alkaloid biosynthesis.
• Lymphadenopathy in saudi arabia.
• Monoterpene Glucosides from Cunila spicata.
• Pyrrolizidine Alkaloids of Senecio vulgaris are Synthesized as N-Oxides in the Roots.
• Qualitative and Quantitative Analysis of the Phenolic Constituents from Orthosiphon aristatus.
• Quinolizidine Alkaloid Composition of Plants and of Photomixotrophic Cell Suspension Cultures of Sarothamnus scoparius and Orobanche rapum-genistae.
• Quinolizidine Alkaloids from Plants and their Cell Suspension Cultures.
• Short interpregnancy interval and the risk of disabling cerebral palsy in a low birth weight population.
• Stratification of breast cancer risk in women with atypia: a Mayo cohort study.
• Suprathel, a new skin substitute, in the management of donor sites of split-thickness skin grafts: results of a clinical study.
• The N-oxides of pyrrolizidine alkaloids: specific uptake by cells, protoplasts and vacuoles from senecio cell cultures.
• [Crash course "clinical research in psychosocial medicine": changes in research knowledge and subjective research competence]
• [Depression and sexual dysfunction: aspects of a multi-faceted relationship]
• [Potentially pre-neoplasics areas in rat's liver associated to chronic use of phenobarbital]