Fewer driver synapses in higher order than in first order thalamic relays.

Fewer driver synapses in higher order than in first order thalamic relays. Research Abstract Details 

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Fewer driver synapses in higher order than in first order thalamic relays. Abstract Text:

S C Van Horn,S M Sherman,

We used electron microscopy to determine the relative numbers of the three synaptic terminal types, RL (round vesicle, large terminal), RS (round vesicles, small terminal), and F (flattened vesicles), found in several representative thalamic nuclei in cats chosen as representative examples of first and higher order thalamic nuclei, where the first order nuclei relay subcortical information mainly to primary sensory cortex, and the higher order nuclei largely relay information from one cortical area to another. The nuclei sampled were the first order ventral posterior nucleus (somatosensory) and the ventral portion of the medial geniculate nucleus (auditory), and the higher order posterior nucleus (somatosensory) and the medial portion of the medial geniculate nucleus (auditory). We found that the relative percentage of synapses from RL terminals varied significantly among these nuclei, these values being higher for first order nuclei (12.6% for the ventral posterior nucleus and 8.2% for the ventral portion of the medial geniculate nucleus) than for the higher order nuclei (5.4% for the posterior nucleus, and 3.5% for the medial portion of the medial geniculate nucleus). This is consistent with a similar analysis of first and higher order nuclei for the visual system (the lateral geniculate nucleus and pulvinar, respectively). Since synapses from RL terminals represent the main information to be relayed, whereas synapses from F and RS terminals are modulatory in function, we conclude that there is relatively more modulation of the thalamic relay in the cortico-thalamo-cortical higher order pathway than in first order relays.

Fewer driver synapses in higher order than in first order thalamic relays. Publishing Authors By Initials

SC Van Horn,SM Sherman,

For similar organic chemicals: carboxylic acids: acids, acyclic: butyric acids: aminobutyric acids: gamma-aminobutyric acid research abstracts see: organic chemicals: carboxylic acids: acids, acyclic: butyric acids: aminobutyric acids: gamma-aminobutyric acid research

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Fewer driver synapses in higher order than in first order thalamic relays. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Neuroscience

VOLUME: 146

Page Numbers: 463-70

Journal Abbreviation:

ISSN: 0306-4522

DAY: 22

MONTH: 02

YEAR: 2007

Fewer driver synapses in higher order than in first order thalamic relays. Information

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LANGUAGE: eng

NlmUniqueID: 7605074

Fewer driver synapses in higher order than in first order thalamic relays. Keywords Mesh Terms:

KEYWORDS: gamma-Aminobutyric Acid

MESH TERMS: metabolism

Chemical & Substance for Abstract: Fewer driver synapses in higher order than in first order thalamic relays. Information

Substance Name: gamma-Aminobutyric Acid

Registry Number: 56-12-2

Grant and Affiliation Information for Fewer driver synapses in higher order than in first order thalamic relays.

AFFILIATION: Department of Neurobiology, State University of New York, Stony Brook, NY 11794-5230, USA.

Country: United States

AGENCY: United States NEI

GRANT: EY03038

ACRONYM: EY

MEDLINETA: Neuroscience

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