Fetal thermal dose considerations during the obstetrician's watch: Implications for the pediatrician's observations.

Fetal thermal dose considerations during the obstetrician's watch: Implications for the pediatrician's observations. Research Abstract Details 

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Fetal thermal dose considerations during the obstetrician's watch: Implications for the pediatrician's observations. Abstract Text:

Morton W Miller,Charles C Church,Richard K Miller,Marsh J Edwards,Morton W Miller,Charles C Church,Richard K Miller,Marsh J Edwards,

There are a number of seemingly "usual" thermal episodes during pregnancy for which it is relatively easy to determine a rudimentary aspect of thermal dose; these episodes include fever, labor, labor plus epidural, and the normally-occurring 0.5 degrees C temperature elevation above maternal core temperature of the fetus during the entirety of the third trimester. Complications can involve, for instance, fever during the third trimester. We consider the thermal doses of five different but "usual" or "normal" hyperthermic episodes during human pregnancy and compare those doses with the thermal doses involved with both single and cohort exposures of pregnant guinea pigs throughout their gestational period. The end-point studied in the guinea pigs was microencephaly. In nine of the 10 comparisons (human fetal thermal dose vs. guinea pig fetal thermal dose) the human dose is substantially larger than that of the guinea pig thermal dose, which was substantially teratogenic. This situation is essentially the inverse of the type of information contained in the Physician's Desk Reference (PDR) on drugs, in which it is not unusual to discern that at high drug levels there may be teratogenic effects in laboratory animals, but such effects were not observed at "clinical" drug levels in animals or subsequent clinical trials. With hyperthermic events, however, it appears that the teratogenically-effective thermal dose levels associated with animal testing are quite low relative to those thermal doses associated with relatively "normal" obstetric observations during a pregnancy.

Fetal thermal dose considerations during the obstetrician's watch: Implications for the pediatrician's observations. Publishing Authors By Initials

MW Miller,CC Church,RK Miller,MJ Edwards,MW Miller,CC Church,RK Miller,MJ Edwards,

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Fetal thermal dose considerations during the obstetrician's watch: Implications for the pediatrician's observations. Journal Published:

PUBLICATION TYPE: Review

Journal: Birth defects research. Part C, Embryo today : rev

VOLUME: 81

Page Numbers: 135-43

Journal Abbreviation: Birth Defects Res. C Embryo To

ISSN: 1542-975X

DAY: 5

MONTH: Sep

YEAR: 2007

Fetal thermal dose considerations during the obstetrician's watch: Implications for the pediatrician's observations. Information

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LANGUAGE: eng

NlmUniqueID: 101167665

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Grant and Affiliation Information for Fetal thermal dose considerations during the obstetrician's watch: Implications for the pediatrician's observations.

AFFILIATION: Department of Obstetrics and Gynecology, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA. Morton_Miller@urmc.rochester.edu

Country: United States

AGENCY: United States NIBIB

GRANT: R37 EB 001329

ACRONYM: EB

MEDLINETA: Birth Defects Res C Embryo Tod

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