Femoral nonunion fracture treated with recombinant human bone morphogenetic protein-2 in a dog.

Femoral nonunion fracture treated with recombinant human bone morphogenetic protein-2 in a dog. Research Abstract Details 

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Femoral nonunion fracture treated with recombinant human bone morphogenetic protein-2 in a dog. Abstract Text:

T Itoh,M Mochizuki,K Fuda,R Nishimura,S Matsunaga,T Kadosawa,N Sasaki,

This is the first report on successful treatment of spontaneous nonunion fracture of a dog by use of recombinant human bone morphogenetic protein-2 (rhBMP-2). A 4-year-old Pomeranian dog with a 2-year history of femoral nonunion fracture was treated with implantation of rhBMP-2. The dog had received surgical correction twice prior to the admission but radiography of the affected limb revealed a typical figure of nonunion fracture. Glossly, the fractured ends were sclerotic and the area between the ends was filled with fibrous tissue. After debridement the femoral shaft was fixed by an 8-hole plate. rhBMP-2 at a total dose of 256 micrograms was implanted with a synthetic carrier into the 8-mm defect formed by the debridement. Callus formation responding to rhBMP-2 was radiographically observed at 2 weeks after implantation and the defect reached radiographic union by 8 weeks after implantation. The plate was removed at 9 months after implantation. Any complications were not observed for 5 months after removal of the plate.

Femoral nonunion fracture treated with recombinant human bone morphogenetic protein-2 in a dog. Publishing Authors By Initials

T Itoh,M Mochizuki,K Fuda,R Nishimura,S Matsunaga,T Kadosawa,N Sasaki,

For similar peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research

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Femoral nonunion fracture treated with recombinant human bone morphogenetic protein-2 in a dog. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Journal of veterinary medical science / the Ja

VOLUME: 60

Page Numbers: 535-8

Journal Abbreviation: J. Vet. Med. Sci.

ISSN: 0916-7250

DAY: 19

MONTH: Apr

YEAR: 1998

Femoral nonunion fracture treated with recombinant human bone morphogenetic protein-2 in a dog. Information

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LANGUAGE: eng

NlmUniqueID: 9105360

Femoral nonunion fracture treated with recombinant human bone morphogenetic protein-2 in a dog. Keywords Mesh Terms:

KEYWORDS: Transforming Growth Factor beta

MESH TERMS: therapeutic use

Chemical & Substance for Abstract: Femoral nonunion fracture treated with recombinant human bone morphogenetic protein-2 in a dog. Information

Substance Name: recombinant human bone morphogenetic pro

Registry Number: 0

Grant and Affiliation Information for Femoral nonunion fracture treated with recombinant human bone morphogenetic protein-2 in a dog.

AFFILIATION: Laboratory of Veterinary Surgery, Graduate School of Agriculture and Life Science, University of Tokyo, Japan.

Country: JAPAN

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MEDLINETA: J Vet Med Sci

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