Felbamate is a subunit selective modulator of recombinant gamma-aminobutyric acid type A receptors expressed in Xenopus oocytes.

Felbamate is a subunit selective modulator of recombinant gamma-aminobutyric acid type A receptors expressed in Xenopus oocytes. Research Abstract Details 

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Felbamate is a subunit selective modulator of recombinant gamma-aminobutyric acid type A receptors expressed in Xenopus oocytes. Abstract Text:

Timothy A Simeone,James F Otto,Karen S Wilcox,H Steve White,

Felbamate (2-phenyl-1,3-propanediol dicarbamate) is clinically available for the treatment of refractory epileptic seizures, and is known to modulate several ion channels including gamma-aminobutyric acid type A (GABA(A)) receptors. To determine felbamate subunit selectivity for GABA(A) receptors we expressed 15 different GABA(A) receptor combinations in Xenopus laevis oocytes. Felbamate positively modulated GABA-currents of alpha(1)beta(2)gamma(2S), alpha(1)beta(3)gamma(2S), alpha(2)beta(2)gamma(2S) and alpha(2)beta(3)gamma(2S), whereas felbamate was either ineffective or negatively modulated the other 11 receptor combinations. Regional distributions of GABA(A) receptor subunits suggest that felbamate may differentially modulate distinct inhibitory circuits, a possibility that may have relevance to felbamate efficacy in refractory epilepsies.

Felbamate is a subunit selective modulator of recombinant gamma-aminobutyric acid type A receptors expressed in Xenopus oocytes. Publishing Authors By Initials

TA Simeone,JF Otto,KS Wilcox,HS White,

For similar organic chemicals: carboxylic acids: acids, acyclic: butyric acids: aminobutyric acids: gamma-aminobutyric acid research abstracts see: organic chemicals: carboxylic acids: acids, acyclic: butyric acids: aminobutyric acids: gamma-aminobutyric acid research

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Felbamate is a subunit selective modulator of recombinant gamma-aminobutyric acid type A receptors expressed in Xenopus oocytes. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: European journal of pharmacology

VOLUME: 552

Page Numbers: 31-5

Journal Abbreviation: Eur. J. Pharmacol.

ISSN: 0014-2999

DAY: 16

MONTH: 09

YEAR: 2006

Felbamate is a subunit selective modulator of recombinant gamma-aminobutyric acid type A receptors expressed in Xenopus oocytes. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 1254354

Felbamate is a subunit selective modulator of recombinant gamma-aminobutyric acid type A receptors expressed in Xenopus oocytes. Keywords Mesh Terms:

KEYWORDS: gamma-Aminobutyric Acid

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Felbamate is a subunit selective modulator of recombinant gamma-aminobutyric acid type A receptors expressed in Xenopus oocytes. Information

Substance Name: Flumazenil

Registry Number: 78755-81-4

Grant and Affiliation Information for Felbamate is a subunit selective modulator of recombinant gamma-aminobutyric acid type A receptors expressed in Xenopus oocytes.

AFFILIATION: Interdepartmental Program in Neuroscience, University of Utah, Salt Lake City, UT 84112-9057, USA.

Country: Netherlands

AGENCY: United States NINDS

GRANT: NS-4-2311

ACRONYM: NS

MEDLINETA: Eur J Pharmacol

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