Feeding a diet containing a fructooligosaccharide mix can enhance salmonella vaccine efficacy in mice.

Feeding a diet containing a fructooligosaccharide mix can enhance salmonella vaccine efficacy in mice. Research Abstract Details 

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Feeding a diet containing a fructooligosaccharide mix can enhance salmonella vaccine efficacy in mice. Abstract Text:

Jalil Benyacoub,Florence Rochat,Kim-Yen Saudan,Isabelle Rochat,Nicolas Antille,Christine Cherbut,Thierry von der Weid,Eduardo J Schiffrin,Stephanie Blum,Jalil Benyacoub,Florence Rochat,Kim-Yen Saudan,Isabelle Rochat,Nicolas Antille,Christine Cherbut,Thierry von der Weid,Eduardo J Schiffrin,Stephanie Blum,Jalil Benyacoub,Florence Rochat,Kim-Yen Saudan,Isabelle Rochat,Nicolas Antille,Christine Cherbut,Thierry von der Weid,Eduardo J Schiffrin,Stephanie Blum,

Fructooligosaccharides (FOS) are considered prebiotics because of their ability to promote growth of specific beneficial gut bacteria, such as bifidobacteria. Some studies reported potential immune-modulating properties. The aim of this study was to investigate the effect of FOS:inulin mix on murine response to Salmonella vaccine and evaluate the relevance toward protection against Salmonella infection. Balb/c mice were fed a diet containing 5% FOS:inulin mix or a control diet 1 wk before oral immunization with a suboptimal dose of live attenuated Salmonella typhimurium vaccine. Four weeks after vaccination, mice were infected with LD100 of virulent S. typhimurium. Specific blood Salmonella immunoglobulin G and fecal immunoglobulin A significantly increased in mice fed the diet containing prebiotics compared with control mice 4 wk postimmunization. Peritoneal macrophage phagocytic activity also significantly increased in FOS:inulin-fed mice at 1 wk postimmunization compared with control mice. No detectable effects were observed on the percentage of lymphoid cell subsets in the spleen. However, production of cytokines, interferon-gamma, interleukin-12, and tumor necrosis factor alpha, was numerically increased in spleen cell cultures stimulated with mitogens from FOS:inulin-fed mice 1 and 4 wk postimmunization. Salmonella translocation to lymphoid organs was not affected by feeding FOS:inulin. However, the improved response to Salmonella vaccine was concomitant with an increase in the survival rate of FOS:inulin-fed mice upon challenge with virulent Salmonella. No detectable effects were observed on the composition or the metabolic activity of the microbiota. Overall, the data suggest that a diet supplemented with FOS:inulin mix stimulates mucosal immunity and seems to improve efficacy of an oral vaccine.

Feeding a diet containing a fructooligosaccharide mix can enhance salmonella vaccine efficacy in mice. Publishing Authors By Initials

J Benyacoub,F Rochat,KY Saudan,I Rochat,N Antille,C Cherbut,T von der Weid,EJ Schiffrin,S Blum,J Benyacoub,F Rochat,KY Saudan,I Rochat,N Antille,C Cherbut,T von der Weid,EJ Schiffrin,S Blum,J Benyacoub,F Rochat,KY Saudan,I Rochat,N Antille,C Cherbut,T von der Weid,EJ Schiffrin,S Blum,

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Feeding a diet containing a fructooligosaccharide mix can enhance salmonella vaccine efficacy in mice. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Journal of nutrition

VOLUME: 138

Page Numbers: 123-9

Journal Abbreviation: J. Nutr.

ISSN: 1541-6100

DAY: 24

MONTH: Jan

YEAR: 2008

Feeding a diet containing a fructooligosaccharide mix can enhance salmonella vaccine efficacy in mice. Information

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LANGUAGE: eng

NlmUniqueID: 404243

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Grant and Affiliation Information for Feeding a diet containing a fructooligosaccharide mix can enhance salmonella vaccine efficacy in mice.

AFFILIATION: Nestlé Research Center, CH-1000, Lausanne 26, Switzerland.

Country: United States

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MEDLINETA: J Nutr

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