Fecal calprotectin level measurements in small bowel allograft monitoring: a pilot study.

Fecal calprotectin level measurements in small bowel allograft monitoring: a pilot study. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Fecal calprotectin level measurements in small bowel allograft monitoring: a pilot study. Abstract Text:

BACKGROUND: Protocol endoscopy with biopsy is currently the gold standard of small bowel transplantation (SBTx) monitoring, however it is invasive, costly, needs skilled operator, may require anesthesia and may cause complications. We investigated fecal calprotectin level (FCL) as a candidate noninvasive marker for monitoring patients after SBTx. METHODS: A pilot study was performed to test the use of FCL measurement in following up SBTx patients. Ileostomy effluents were collected at various postoperative days before endoscopy and biopsy. FCLs were measured by enzyme-linked immunosorbent assay and a cut-off level of 100 ng/mg was considered positive. The results were retrospectively evaluated in combination with clinical, endoscopic, and histopathological findings. FCLs are presented as median nanogram per milligram. RESULTS: FCLs were measured in 122 samples that were obtained from 29 patients after SBTx. Only 1 of 69 positive FCL did not accompany abnormal findings. Retrospective evaluation showed that 11 samples from six patients (FCL: 217) coincided with rejection episodes, six samples from three patients (FCL: 125) coincided with viral enteritis, 51 samples from 21 patients (FCL: 207) coincided with nonspecific inflammation, 11 samples from two patients (FCL: 998) coincided with chronic intestinal ulceration, and finally 50 samples from 19 patients (FCL: 43) coincided with normal findings. No significant FCL difference was found between rejection, infection, and inflammation. FCL evolution in individuals showed that FCL can predict rejection days before histopathological diagnosis. CONCLUSION: FCL is a sensitive test for ongoing organic intestinal allograft pathologies. It might be useful as prescreening marker to avoid unnecessary endoscopies.

Fecal calprotectin level measurements in small bowel allograft monitoring: a pilot study. Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Fecal calprotectin level measurements in small bowel allograft monitoring: a pilot study. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Transplantation

VOLUME: 85

Page Numbers: 1281-6

Journal Abbreviation: Transplantation

ISSN: 0041-1337

DAY: 15

MONTH: May

YEAR: 2008

Fecal calprotectin level measurements in small bowel allograft monitoring: a pilot study. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 132144

Fecal calprotectin level measurements in small bowel allograft monitoring: a pilot study. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Fecal calprotectin level measurements in small bowel allograft monitoring: a pilot study. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Fecal calprotectin level measurements in small bowel allograft monitoring: a pilot study.

AFFILIATION: Miami Transplant Institute, University of Miami School of Medicine, Miami, FL 33136, USA. eakpinar@med.miami.edu

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Transplantation

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Fecal calprotectin level measurements in small bowel allograft monitoring: a pilot study Related Publications

• Alveolar Echinococcosis induced liver failure: salvage by liver transplantation in an otherwise uniformly fatal disease.
• Anesthetic and perioperative management of intestinal and multivisceral allograft recipient in nontransplant surgery.
• Aortohepatic conduits: a personal commentary.
• Expression of MUC2 and MUC4 proteins and cytokines: early markers of intestinal graft rejection.
• Fecal calprotectin level measurements in small bowel allograft monitoring: a pilot study.
• Inclusion of donor colon and ileocecal valve in intestinal transplantation.
• Liver transplantation at the Miami Transplant Institute: a 14-year single-center experience.
• Partial bladder transplantation with en bloc kidney transplant--the first case report of a 'bladder patch technique' in a human.
• Piggyback technique in adult orthotopic liver transplantation: an analysis of 1067 liver transplants at a single center.
• Randomized trial of steroid-free induction versus corticosteroid maintenance among orthotopic liver transplant recipients with hepatitis C virus: impact on hepatic fibrosis progression at one year.
• Rescue of acute complete portal vein occlusion with Doppler ultrasound findings after liver transplantation.
• Right trisectionectomy of the liver for intrahepatic cholangiocarcinoma with bile duct invasion in a Jehovah's Witness.
• Tacrolimus does not upregulate mucin gene expression after small bowel transplantation in rats.