Feasibility of an electrode-reservoir device for transdermal drug delivery by noninvasive skin electroporation.

Feasibility of an electrode-reservoir device for transdermal drug delivery by noninvasive skin electroporation. Research Abstract Details 

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Feasibility of an electrode-reservoir device for transdermal drug delivery by noninvasive skin electroporation. Abstract Text:

Uwe Pliquett,James C Weaver,Uwe Pliquett,James C Weaver,

Electrical creation of aqueous pathways across the skin's outer layer [stratum corneum (SC)] provides an approach to transdermal delivery of medium-size water-soluble compounds. However, nerve stimulation should be avoided. Here, we show that a microstructured electrode array can significantly confine the electric field to the nerve-free SC. The prototype electrode-reservoir device (ERD) contains field-confining electrodes and a fluorescent drug surrogate [sulphorhodamine (SR)]. In vivo human experiments at the forearm with approximately rectangular voltage pulses up to 500 V and 1-ms duration cause electroporation as measured by skin resistance change but only rarely caused sensation. Human skin in vitro experiments with such pulses up to 300 V transported SR across the SC. Our results are supported by a model's prediction of the field in the ERD and nearby tissue.

Feasibility of an electrode-reservoir device for transdermal drug delivery by noninvasive skin electroporation. Publishing Authors By Initials

U Pliquett,JC Weaver,U Pliquett,JC Weaver,

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Feasibility of an electrode-reservoir device for transdermal drug delivery by noninvasive skin electroporation. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: IEEE transactions on bio-medical engineering

VOLUME: 54

Page Numbers: 536-8

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ISSN: 0018-9294

DAY: 14

MONTH: Mar

YEAR: 2007

Feasibility of an electrode-reservoir device for transdermal drug delivery by noninvasive skin electroporation. Information

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LANGUAGE: eng

NlmUniqueID: 12737

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Grant and Affiliation Information for Feasibility of an electrode-reservoir device for transdermal drug delivery by noninvasive skin electroporation.

AFFILIATION: Institut für Bioprozess-und Analysenmesstechnik e.V., Heilbad Heiligenstadt 37308, Germany. Uwe.Pliquett@iba-heiligenstadt.de

Country: United States

AGENCY: United States NIGMS

GRANT: R01-GM63857

ACRONYM: GM

MEDLINETA: IEEE Trans Biomed Eng

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