Feasibility evaluation of emodin (rhubarb extract) as an inhibitor of pancreatic cancer cell proliferation in vitro.

Feasibility evaluation of emodin (rhubarb extract) as an inhibitor of pancreatic cancer cell proliferation in vitro. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Feasibility evaluation of emodin (rhubarb extract) as an inhibitor of pancreatic cancer cell proliferation in vitro. Abstract Text:

Emodin is a commonly used traditional herbal treatment in China, including use for pancreatic malignancy. In this study, the potential for emodin to inhibit pancreatic cancer cell proliferation was examined using 4 human pancreatic adenocarcinoma cell lines: Mia Paca-2, BxPC-3, Panc-1, and L3.6pl. WST-1 proliferation, propidium iodide flow cytometry cell cycle analysis, and poly-ADP-ribose polymerase (PARP) Western blot analysis were performed. Forty-eight-hour treatment with 50 muM emodin inhibited proliferation in Mia Paca-2 cells by 42%, BxPc-3 by 38%, L3.6pl by 56%, and Panc-1 by 18% (all P < .01). In three-fourths of the cell lines, emodin treatment resulted in an increase (from 4.7% to 22%) in the cell population number in apoptosis when measured by flow cytometric analysis. Mia Paca-2 revealed a significant PARP cleavage product when compared with control. These feasibility experiments provide initial evidence that emodin exerts an antiproliferative effect, likely through apoptosis induction-related mechanism(s), that is reproducible in various human pancreatic cancer cell lines.

Feasibility evaluation of emodin (rhubarb extract) as an inhibitor of pancreatic cancer cell proliferation in vitro. Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Feasibility evaluation of emodin (rhubarb extract) as an inhibitor of pancreatic cancer cell proliferation in vitro. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: JPEN. Journal of parenteral and enteral nutrition

VOLUME: 32

Page Numbers: 190-6

Journal Abbreviation:

ISSN: 0148-6071

DAY: 14

MONTH: 04

YEAR: 2008

Feasibility evaluation of emodin (rhubarb extract) as an inhibitor of pancreatic cancer cell proliferation in vitro. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7804134

Feasibility evaluation of emodin (rhubarb extract) as an inhibitor of pancreatic cancer cell proliferation in vitro. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Feasibility evaluation of emodin (rhubarb extract) as an inhibitor of pancreatic cancer cell proliferation in vitro. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Feasibility evaluation of emodin (rhubarb extract) as an inhibitor of pancreatic cancer cell proliferation in vitro.

AFFILIATION: Department of Surgery, The University of Illinois at Chicago.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: JPEN J Parenter Enteral Nutr

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Feasibility evaluation of emodin rhubarb extract as an inhibitor of pancreatic cancer cell proliferation in vitro Related Publications

• Attenuation of iNOS in an LPS-Stimulated Macrophage Model by Omega-3 Fatty Acids is Independent of COX-2 Derived PGE(2).
• Combined major hepatectomy and pancreaticoduodenectomy for biliary cancer: challenging procedure in the most experienced centers.
• Feasibility evaluation of emodin (rhubarb extract) as an inhibitor of pancreatic cancer cell proliferation in vitro.
• G2/M cell-cycle arrest and apoptosis by n-3 fatty acids in a pancreatic cancer model.
• Gastric adenocarcinoma arising from fundic gland polyps in a patient with familial adenomatous polyposis syndrome.
• Inhibition of proliferation by omega-3 Fatty acids in chemoresistant pancreatic cancer cells.
• Lipopolysaccharide-Stimulated RAW 264.7 Macrophage Inducible Nitric Oxide Synthase and Nitric Oxide Production Is Decreased by an Omega-3 Fatty Acid Lipid Emulsion.
• Radiofrequency ablation of primary and metastatic liver tumors: a critical review of the literature.
• The abdominal cocoon: a rare cause of intestinal obstruction in two patients.
• Use of radiofrequency hepatic parenchymal transection device in hepatic hemangioma resection: early experience and lessons learned.