FcgammaRII and multi-system autoimmune disease.

FcgammaRII and multi-system autoimmune disease. Research Abstract Details 

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FcgammaRII and multi-system autoimmune disease. Abstract Text:

Nicholas C van de Velde,Patricia L Mottram,P Mark Hogarth,

The FcR are a crucial link in the immune response between humoral and cellular immunity and cell-based effector systems, mediating a wide variety of physiological and biochemical responses. The FcR for IgG (FcgammaR) and in particular the most widely expressed of these, FcgammaRII, are important in regulating adaptive immunity. Disruption of their function is a key factor in the development of autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), which are characterized by chronic, multi-organ inflammation. Studies of the FcgammaRII include structure/function relationships, investigation of the associations between FcR polymorphisms and human disease and animal studies using knockout or transgenic mouse models. These investigations showed that the various forms of FcgammaRII interact with immune complexes to either initiate or inhibit inflammation. In conjunction with environmental antigens and genotype, the FcgammaRII activating and inhibitory receptors determine the nature and magnitude of response to antigens. In this review, the structure and function of the FcgammaRIIs and their role in immune complex-mediated auto-immunity are discussed.

FcgammaRII and multi-system autoimmune disease. Publishing Authors By Initials

NC van de Velde,PL Mottram,PM Hogarth,

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FcgammaRII and multi-system autoimmune disease. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Springer seminars in immunopathology

VOLUME: 28

Page Numbers: 329-38

Journal Abbreviation: Springer Semin. Immunopathol.

ISSN: 0344-4325

DAY: 8

MONTH: 11

YEAR: 2006

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LANGUAGE: eng

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AFFILIATION: Burnet Institute (Austin Campus), Austin Hospital, Studley Road, Heidelberg, Victoria, 3084, Australia, pm.hogarth@burnet.edu.au.

Country: Germany

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MEDLINETA: Springer Semin Immunopathol

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