Fc receptor homolog 3 is a novel immunoregulatory marker of marginal zone and B1 B cells.

Fc receptor homolog 3 is a novel immunoregulatory marker of marginal zone and B1 B cells. Research Abstract Details 

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Fc receptor homolog 3 is a novel immunoregulatory marker of marginal zone and B1 B cells. Abstract Text:

Woong-Jai Won,Jeremy B Foote,Mary R Odom,Jicun Pan,John F Kearney,Randall S Davis,

Two members of the recently identified FcR homolog (FcRH) family in mice demonstrate preferential B cell expression. One of these, FcRH3, encodes a type I transmembrane protein with five extracellular Ig domains and a cytoplasmic tail with a consensus ITIM and a noncanonical ITAM. Analysis of full-length cDNAs from five different mouse strains defines two FcRH3 alleles. A panel of FcRH3-specific mAbs was generated to define its expression pattern and functional potential on B lineage cells. Although poorly detected on the majority of bone marrow or peripheral blood cells, FcRH3 was readily identified on splenic marginal zone (MZ) and MZ precursor B cells, but not on the bulk of newly formed B cells, follicular B cells, germinal center B cells, and plasma cells. In the peritoneal cavity, FcRH3 was found on B1 cells, and not on the majority of B2 cells. Consistent with its possession of an ITIM and ITAM-like sequence, FcRH3 was tyrosine phosphorylated following pervanadate treatment, and its coligation with the BCR inhibited calcium mobilization. These results suggest FcRH3 is a novel immunoregulatory marker of MZ and B1 B lineage cells.

Fc receptor homolog 3 is a novel immunoregulatory marker of marginal zone and B1 B cells. Publishing Authors By Initials

WJ Won,JB Foote,MR Odom,J Pan,JF Kearney,RS Davis,

For similar cells: stem cells research abstracts see: cells: stem cells research

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Fc receptor homolog 3 is a novel immunoregulatory marker of marginal zone and B1 B cells. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of immunology (Baltimore, Md. : 1950)

VOLUME: 177

Page Numbers: 6815-23

Journal Abbreviation: J. Immunol.

ISSN: 0022-1767

DAY: 15

MONTH: Nov

YEAR: 2006

Fc receptor homolog 3 is a novel immunoregulatory marker of marginal zone and B1 B cells. Information

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LANGUAGE: eng

NlmUniqueID: 2985117

Fc receptor homolog 3 is a novel immunoregulatory marker of marginal zone and B1 B cells. Keywords Mesh Terms:

KEYWORDS: Stem Cells

MESH TERMS: metabolism

Chemical & Substance for Abstract: Fc receptor homolog 3 is a novel immunoregulatory marker of marginal zone and B1 B cells. Information

Substance Name: Receptors, Fc

Registry Number: 0

Grant and Affiliation Information for Fc receptor homolog 3 is a novel immunoregulatory marker of marginal zone and B1 B cells.

AFFILIATION: Division of Developmental and Clinical Immunology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

Country: United States

AGENCY: United States NIAID

GRANT: K08 AI55638

ACRONYM: AI

MEDLINETA: J Immunol

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