FBXO40, a gene encoding a novel muscle-specific F-box protein, is upregulated in denervation-related muscle atrophy.

FBXO40, a gene encoding a novel muscle-specific F-box protein, is upregulated in denervation-related muscle atrophy. Research Abstract Details 

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FBXO40, a gene encoding a novel muscle-specific F-box protein, is upregulated in denervation-related muscle atrophy. Abstract Text:

Jianwei Ye,Yong Zhang,Jialin Xu,Qiang Zhang,Dahai Zhu,Jianwei Ye,Yong Zhang,Jialin Xu,Qiang Zhang,Dahai Zhu,Jianwei Ye,Yong Zhang,Jialin Xu,Qiang Zhang,Dahai Zhu,Jianwei Ye,Yong Zhang,Jialin Xu,Qiang Zhang,Dahai Zhu,

F-box proteins are key components of SCF (Skp1-Cullin1-F-box protein) complexes, which exert E3 ubiquitin ligase activity and participate in cell cycle and signal transduction. F-box proteins interact with Skp1 through the F-box domain and with proteins to be ubiquitinated through other interaction domains. We have characterized a novel muscle-specific F-box protein, FBXO40, the expression of which decreases in the dystrophic muscle of Limb-girdle muscular dystrophy (LGMD) patient. During the development of skeletal muscle, FBXO40 can only be detected at postnatal stage from about 2 weeks after birth. By overexpressing in C2C12 cells, FBXO40 localized in cytoplasm. Most importantly, the expression of FBXO40 can be upregulated in skeletal muscle from denervation- but not starvation-related muscle atrophy. All our data suggest that FBXO40 may function as a regulator involved in the postnatal myogenesis.

FBXO40, a gene encoding a novel muscle-specific F-box protein, is upregulated in denervation-related muscle atrophy. Publishing Authors By Initials

J Ye,Y Zhang,J Xu,Q Zhang,D Zhu,J Ye,Y Zhang,J Xu,Q Zhang,D Zhu,J Ye,Y Zhang,J Xu,Q Zhang,D Zhu,J Ye,Y Zhang,J Xu,Q Zhang,D Zhu,

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FBXO40, a gene encoding a novel muscle-specific F-box protein, is upregulated in denervation-related muscle atrophy. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Gene

VOLUME: 404

Page Numbers: 53-60

Journal Abbreviation: Gene

ISSN: 0378-1119

DAY: 7

MONTH: 09

YEAR: 2007

FBXO40, a gene encoding a novel muscle-specific F-box protein, is upregulated in denervation-related muscle atrophy. Information

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LANGUAGE: eng

NlmUniqueID: 7706761

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Grant and Affiliation Information for FBXO40, a gene encoding a novel muscle-specific F-box protein, is upregulated in denervation-related muscle atrophy.

AFFILIATION: National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, 5 Dong Dan San Tiao, Beijing 100005, PR China.

Country: Netherlands

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MEDLINETA: Gene

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