Fatty acid desaturation and the regulation of adiposity in Caenorhabditis elegans.

Fatty acid desaturation and the regulation of adiposity in Caenorhabditis elegans. Research Abstract Details 

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Fatty acid desaturation and the regulation of adiposity in Caenorhabditis elegans. Abstract Text:

Trisha J Brock,John Browse,Jennifer L Watts,

Monounsaturated fatty acids are essential components of membrane and storage lipids. Their synthesis depends on the conversion of saturated fatty acids to unsaturated fatty acids by Delta9 desaturases. Caenorhabditis elegans has three Delta9 desaturases encoded by the genes fat-5, fat-6, and fat-7. We generated nematodes that display a range of altered fatty acid compositions by constructing double-mutant strains that combine mutations in fat-5, fat-6, and fat-7. All three double-mutant combinations have reduced survival at low temperatures. The fat-5;fat-6 double mutants display relatively subtle fatty acid composition alterations under standard conditions, but extreme fatty acid composition changes and reduced survival in the absence of food. The strain with the most severe defect in the production of unsaturated fatty acids, fat-6;fat-7, exhibits slow growth and reduced fertility. Strikingly, the fat-6;fat-7 double-mutant animals have decreased fat stores and increased expression of genes involved in fatty acid oxidation. We conclude that the Delta9 desaturases, in addition to synthesizing unsaturated fatty acids for properly functioning membranes, play key roles in lipid partitioning and in the regulation of fat storage.

Fatty acid desaturation and the regulation of adiposity in Caenorhabditis elegans. Publishing Authors By Initials

TJ Brock,J Browse,JL Watts,

For similar genetic phenomena: variation (genetics): mutation research abstracts see: genetic phenomena: variation (genetics): mutation research

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Fatty acid desaturation and the regulation of adiposity in Caenorhabditis elegans. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Genetics

VOLUME: 176

Page Numbers: 865-75

Journal Abbreviation: Genetics

ISSN: 0016-6731

DAY: 15

MONTH: 04

YEAR: 2007

Fatty acid desaturation and the regulation of adiposity in Caenorhabditis elegans. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 374636

Fatty acid desaturation and the regulation of adiposity in Caenorhabditis elegans. Keywords Mesh Terms:

KEYWORDS: Mutation

MESH TERMS: analysis

Chemical & Substance for Abstract: Fatty acid desaturation and the regulation of adiposity in Caenorhabditis elegans. Information

Substance Name: Fatty Acid Desaturases

Registry Number: EC 1.14.99.-

Grant and Affiliation Information for Fatty acid desaturation and the regulation of adiposity in Caenorhabditis elegans.

AFFILIATION: Institute of Biological Chemistry, Washington State University, Pullman, Washington 99164-6340, USA.

Country: United States

AGENCY: United States NIDDK

GRANT: R01 DK074114

ACRONYM: DK

MEDLINETA: Genetics

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