Fates of mouse embryonic stem cells transplanted into the inner ears of adult mice and embryonic chickens.

Fates of mouse embryonic stem cells transplanted into the inner ears of adult mice and embryonic chickens. Research Abstract Details 

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Fates of mouse embryonic stem cells transplanted into the inner ears of adult mice and embryonic chickens. Abstract Text:

Tatsunori Sakamoto,Takayuki Nakagawa,Tsuyoshi Endo,Tae-Soo Kim,Fukuichiro Iguchi,Yasushi Naito,Yoshiki Sasai,Juichi Ito,

The potential of embryonic stem (ES) cells to differentiate into inner ear hair cells was examined in this study. Undifferentiated mouse ES cells transplanted into neomycin-damaged mouse inner ears were evaluated by immunohistochemistry 4 weeks after transplantation. Some ES cells were positive for E-cadherin or NCAM, and most transplanted cells were positive for SSEA3 and Ki67. None were positive for Myosin VIIa or MF20. These results indicate that the damaged inner ear may have some activity inducing ES cells to develop into ectoderm cells, but the effect was insufficient to induce inner ear hair cells. Next, SDIA/BMP-treated ES cells were transplanted into embryonic chicken inner ear rudiments. Embryonic chickens were expected to share the same developmental systems as mice. SDIA/BMP treatment drove ES cells to the population including neural crest cells and probably placode cells ES colonies were found next to or in the otic vesicles but were not a part of vesicle walls, indicating that transplanted ES cells could not be expected to be the same kind of cells as chicken otic vesicle cells Some ES colonies were found at the vestibulo-cochlear ganglions. To induce inner ear hair cells in this system, the competency of ES cells and otic induction signals should be defined further.

Fates of mouse embryonic stem cells transplanted into the inner ears of adult mice and embryonic chickens. Publishing Authors By Initials

T Sakamoto,T Nakagawa,T Endo,TS Kim,F Iguchi,Y Naito,Y Sasai,J Ito,

For similar surgical procedures, operative: transplantation: cell transplantation: stem cell transplantation research abstracts see: surgical procedures, operative: transplantation: cell transplantation: stem cell transplantation research

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Fates of mouse embryonic stem cells transplanted into the inner ears of adult mice and embryonic chickens. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Acta oto-laryngologica. Supplementum

VOLUME:

Page Numbers: 48-52

Journal Abbreviation:

ISSN: 0365-5237

DAY: 13

MONTH: Mar

YEAR: 2004

Fates of mouse embryonic stem cells transplanted into the inner ears of adult mice and embryonic chickens. Information

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LANGUAGE: eng

NlmUniqueID: 370355

Fates of mouse embryonic stem cells transplanted into the inner ears of adult mice and embryonic chickens. Keywords Mesh Terms:

KEYWORDS: Stem Cell Transplantation

MESH TERMS: methods

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Grant and Affiliation Information for Fates of mouse embryonic stem cells transplanted into the inner ears of adult mice and embryonic chickens.

AFFILIATION: Department of Otolaryngology--Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Country: Norway

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MEDLINETA: Acta Otolaryngol Suppl

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