Fast forward to new genes in mammalian reproduction.

Fast forward to new genes in mammalian reproduction. Research Abstract Details 

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Fast forward to new genes in mammalian reproduction. Abstract Text:

Bjarte Furnes,John Schimenti,

The study of reproductive genetics in mammals has lagged behind that of simpler and more tractable model organisms, such as D. melanogaster, C. elegans and various yeast models. Although much valuable information has been generated using these organisms, they do not model the genetic and biological complexity of mammalian reproduction. Thus, the majority of genes required for gametogenesis in mammals remain unidentified. To expand on the existing knowledge of mammalian reproductive genetics, we have carried out forward genetic screens in mice to identify infertility mutants and the underlying mutant genes. Two different approaches were used: mutagenesis of the germline in whole mice, and mutagenesis of embryonic stem cells. This was followed by two- or three-generation breeding schemes to identify pedigrees segregating infertility mutations, which were then phenotypically characterized, genetically mapped, and in some cases, positionally cloned. This whole-genome approach has generated a wide collection of mutants with defects ranging from problems with germ cell development to abnormal sperm morphology. These models have allowed us to study the genetics, as well as the physiology, of reproduction in mammals. This review focuses on describing some of the genes identified in these screens and the ongoing effort to characterize additional mutants.

Fast forward to new genes in mammalian reproduction. Publishing Authors By Initials

B Furnes,J Schimenti,

For similar reproductive and urinary physiology: reproduction research abstracts see: reproductive and urinary physiology: reproduction research

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Fast forward to new genes in mammalian reproduction. Journal Published:

PUBLICATION TYPE: Review

Journal: The Journal of physiology

VOLUME: 578

Page Numbers: 25-32

Journal Abbreviation: J. Physiol. (Lond.)

ISSN: 0022-3751

DAY: 14

MONTH: 09

YEAR: 2006

Fast forward to new genes in mammalian reproduction. Information

Number of References: 46

LANGUAGE: eng

NlmUniqueID: 266262

Fast forward to new genes in mammalian reproduction. Keywords Mesh Terms:

KEYWORDS: Reproduction

MESH TERMS: physiology

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Grant and Affiliation Information for Fast forward to new genes in mammalian reproduction.

AFFILIATION: Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, T9014A, Ithaca, NY 14853, USA.

Country: England

AGENCY: United States NICHD

GRANT: HD42137

ACRONYM: HD

MEDLINETA: J Physiol

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