Family history of hematopoietic malignancies and risk of non-Hodgkin lymphoma (NHL): a pooled analysis of 10 211 cases and 11 905 controls from the International Lymphoma Epidemiology Consortium (InterLymph).

Family history of hematopoietic malignancies and risk of non-Hodgkin lymphoma (NHL): a pooled analysis of 10 211 cases and 11 905 controls from the International Lymphoma Epidemiology Consortium (InterLymph). Research Abstract Details 

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Family history of hematopoietic malignancies and risk of non-Hodgkin lymphoma (NHL): a pooled analysis of 10 211 cases and 11 905 controls from the International Lymphoma Epidemiology Consortium (InterLymph). Abstract Text:

Sophia S Wang,Susan L Slager,Paul Brennan,Elizabeth A Holly,Silvia De Sanjose,Leslie Bernstein,Paolo Boffetta,James R Cerhan,Marc Maynadie,John J Spinelli,Brian C H Chiu,Pier Luigi Cocco,Fiona Mensah,Yawei Zhang,Alexandra Nieters,Luigino Dal Maso,Paige M Bracci,Adele Seniori Costantini,Paolo Vineis,Richard K Severson,Eve Roman,Wendy Cozen,Dennis Weisenburger,Scott Davis,Silvia Franceschi,Carlo La Vecchia,Lenka Foretova,Nikolaus Becker,Anthony Staines,Martine Vornanen,Tongzhang Zheng,Patricia Hartge,

A role for genetic susceptibility in non-Hodgkin lymphoma (NHL) is supported by the accumulating evidence of common genetic variations altering NHL risk. However, the pattern of NHL heritability remains poorly understood. We conducted a pooled analysis of 10 211 NHL cases and 11 905 controls from the International Lymphoma Epidemiology Consortium (InterLymph) to evaluate NHL risk among those with hematopoietic malignancies in first-degree relatives. Odds ratios (ORs) and 95% confidence intervals (CIs) of NHL and its subtypes were estimated from unconditional logistic regression models with adjustment for confounders. NHL risk was elevated for individuals who reported first-degree relatives with NHL (OR = 1.5; 95% CI = 1.2-1.9), Hodgkin lymphoma (OR = 1.6; 95% CI = 1.1-2.3), and leukemia (OR = 1.4; 95% CI = 1.2-2.7). Risk was highest among individuals who reported a brother with NHL (OR = 2.8; 95% CI = 1.6-4.8) and was consistent for all NHL subtypes evaluated. If a first-degree relative had Hodgkin lymphoma, NHL risk was highest if the relative was a parent (OR = 1.7; 95% CI = 1.0-2.9). If a first-degree relative had leukemia, NHL risk was highest among women who reported a sister with leukemia (OR = 3.0; 95% CI = 1.6-5.6). The pattern of NHL heritability appeared to be uniform across NHL subtypes, but risk patterns differed by specific hematopoietic malignancies and the sex of the relative, revealing critical clues to disease etiology.

Family history of hematopoietic malignancies and risk of non-Hodgkin lymphoma (NHL): a pooled analysis of 10 211 cases and 11 905 controls from the International Lymphoma Epidemiology Consortium (InterLymph). Publishing Authors By Initials

SS Wang,SL Slager,P Brennan,EA Holly,S De Sanjose,L Bernstein,P Boffetta,JR Cerhan,M Maynadie,JJ Spinelli,BC Chiu,PL Cocco,F Mensah,Y Zhang,A Nieters,L Dal Maso,PM Bracci,AS Costantini,P Vineis,RK Severson,E Roman,W Cozen,D Weisenburger,S Davis,S Franceschi,C La Vecchia,L Foretova,N Becker,A Staines,M Vornanen,T Zheng,P Hartge,

For similar epidemiologic factors: sex factors research abstracts see: epidemiologic factors: sex factors research

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Family history of hematopoietic malignancies and risk of non-Hodgkin lymphoma (NHL): a pooled analysis of 10 211 cases and 11 905 controls from the International Lymphoma Epidemiology Consortium (InterLymph). Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Blood

VOLUME: 109

Page Numbers: 3479-88

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ISSN: 0006-4971

DAY: 21

MONTH: 12

YEAR: 2006

Family history of hematopoietic malignancies and risk of non-Hodgkin lymphoma (NHL): a pooled analysis of 10 211 cases and 11 905 controls from the International Lymphoma Epidemiology Consortium (InterLymph). Information

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LANGUAGE: eng

NlmUniqueID: 7603509

Family history of hematopoietic malignancies and risk of non-Hodgkin lymphoma (NHL): a pooled analysis of 10 211 cases and 11 905 controls from the International Lymphoma Epidemiology Consortium (InterLymph). Keywords Mesh Terms:

KEYWORDS: Sex Factors

MESH TERMS: genetics

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Grant and Affiliation Information for Family history of hematopoietic malignancies and risk of non-Hodgkin lymphoma (NHL): a pooled analysis of 10 211 cases and 11 905 controls from the International Lymphoma Epidemiology Consortium (InterLymph).

AFFILIATION: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Bethesda, MD 20892, USA. wangso@mail.nih.gov

Country: United States

AGENCY: United States NCI

GRANT: PC 71105

ACRONYM: PC

MEDLINETA: Blood

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