Family-based association study of matrix metalloproteinase-3 and -9 haplotypes with susceptibility to ischemic white matter injury.

Family-based association study of matrix metalloproteinase-3 and -9 haplotypes with susceptibility to ischemic white matter injury. Research Abstract Details 

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Family-based association study of matrix metalloproteinase-3 and -9 haplotypes with susceptibility to ischemic white matter injury. Abstract Text:

Myriam Fornage,Thomas H Mosley,Clifford R Jack,Mariza de Andrade,Sharon L R Kardia,Eric Boerwinkle,Stephen T Turner,

Susceptibility to ischemic damage to the subcortical white matter of the brain has a strong genetic basis. Dysregulation of matrix metalloproteinases (MMPs) contributes to loss of cerebrovascular integrity and white matter injury. We investigated whether sequence variation in the genes encoding MMP3 and MMP9 is associated with variation in leukoaraiosis volume, determined by magnetic resonance imaging, in non-Hispanic whites and African-Americans using family-based association tests. Seven hundred and fifty-six white and 671 African-American individuals from sibships ascertained through two or more siblings with hypertension were genotyped for 7 and 8 haplotype-tagging polymorphisms in the MMP3 and MMP9 genes, respectively. MMP3 sequence variation was significantly associated with variation in leukoaraiosis volume in Whites. Two common haplotypes with opposing relationships to leukoaraiosis volume were identified. MMP9 sequence variation was also significantly associated with variation in leukoaraiosis volume in both African-Americans and Whites. Different haplotypes contributed to these associations in the two racial groups. These findings add to the growing body of evidence from animal models and human clinical studies suggesting a role of MMPs in ischemic white matter injury. They provide the basis for further investigation of the role of these genes in susceptibility and/or progression to clinical disease.

Family-based association study of matrix metalloproteinase-3 and -9 haplotypes with susceptibility to ischemic white matter injury. Publishing Authors By Initials

M Fornage,TH Mosley,CR Jack,M de Andrade,SL Kardia,E Boerwinkle,ST Turner,

For similar behavior and behavior mechanisms: psychology, social: family: nuclear family: siblings research abstracts see: behavior and behavior mechanisms: psychology, social: family: nuclear family: siblings research

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Family-based association study of matrix metalloproteinase-3 and -9 haplotypes with susceptibility to ischemic white matter injury. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Human genetics

VOLUME: 120

Page Numbers: 671-80

Journal Abbreviation: Hum. Genet.

ISSN: 0340-6717

DAY: 22

MONTH: 09

YEAR: 2006

Family-based association study of matrix metalloproteinase-3 and -9 haplotypes with susceptibility to ischemic white matter injury. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7613873

Family-based association study of matrix metalloproteinase-3 and -9 haplotypes with susceptibility to ischemic white matter injury. Keywords Mesh Terms:

KEYWORDS: Siblings

MESH TERMS: genetics

Chemical & Substance for Abstract: Family-based association study of matrix metalloproteinase-3 and -9 haplotypes with susceptibility to ischemic white matter injury. Information

Substance Name: Matrix Metalloproteinase 9

Registry Number: EC 3.4.24.35

Grant and Affiliation Information for Family-based association study of matrix metalloproteinase-3 and -9 haplotypes with susceptibility to ischemic white matter injury.

AFFILIATION: Institute of Molecular Medicine, University of Texas Health Science Center at Houston, 1825 Pressler St., Room 530.G, Houston, TX 77030, USA. myriam.fornage@uth.tmc.edu

Country: Germany

AGENCY: United States NINDS

GRANT: NS41558

ACRONYM: NS

MEDLINETA: Hum Genet

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