Familial Mediterranean fever gene and protection against asthma.

Familial Mediterranean fever gene and protection against asthma. Research Abstract Details 

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Familial Mediterranean fever gene and protection against asthma. Abstract Text:

Einat Rabinovitch,Dror Harats,Pnina Yaron,Tamar Luvish,Merav Lidar,Ron Kedem,Aviv Shaish,Issahar Ben-Dov,Avi Livneh,Einat Rabinovitch,Dror Harats,Pnina Yaron,Tamar Luvish,Merav Lidar,Ron Kedem,Aviv Shaish,Issahar Ben-Dov,Avi Livneh,

BACKGROUND: Asthma is an inflammatory airway disease caused by interaction between susceptibility genes and diverse environmental factors. In Israel, asthma seems to be familial and more severe in patients of Iraqi Jewish descent. On the other hand, asthma is less frequent in individuals with familial Mediterranean fever, an autoinflammatory disease prevalent in the Iraqi Jewish community and linked to mutations in the familial Mediterranean fever gene, designated MEFV. OBJECTIVES: To explore a possible role for mutated MEFV in the reduced susceptibility to asthma and to determine its expression in Israeli subjects of Iraqi origins. METHODS: Using a case-control approach, we studied the presence of the 3 most common MEFV mutations (M694V, V726A, and E148Q) in DNA samples from 75 patients with asthma and 45 asymptomatic first-degree relatives, all of Iraqi Jewish origin. The severity of asthma was evaluated using a published severity score. RESULTS: Eleven patients with asthma and 14 of their relatives carried 1 or 2 mutations in the MEFV gene, a carrier rate significantly lower in patients with asthma than in their first-degree relatives and in ethnically matched healthy individuals (P < .03 and P < .003, respectively). Carriers of MEFV mutations had less severe disease, compared with noncarriers (P < .002). CONCLUSION: These findings suggest that MEFV mutations may have a protective effect in the pathogenesis of asthma.

Familial Mediterranean fever gene and protection against asthma. Publishing Authors By Initials

E Rabinovitch,D Harats,P Yaron,T Luvish,M Lidar,R Kedem,A Shaish,I Ben-Dov,A Livneh,E Rabinovitch,D Harats,P Yaron,T Luvish,M Lidar,R Kedem,A Shaish,I Ben-Dov,A Livneh,

For similar genetic phenomena: variation (genetics): polymorphism, genetic: polymorphism, single nucleotide research abstracts see: genetic phenomena: variation (genetics): polymorphism, genetic: polymorphism, single nucleotide research

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Familial Mediterranean fever gene and protection against asthma. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Annals of allergy, asthma & immunology : official

VOLUME: 99

Page Numbers: 517-21

Journal Abbreviation: Ann. Allergy Asthma Immunol.

ISSN: 1081-1206

DAY: 19

MONTH: Dec

YEAR: 2007

Familial Mediterranean fever gene and protection against asthma. Information

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LANGUAGE: eng

NlmUniqueID: 9503580

Familial Mediterranean fever gene and protection against asthma. Keywords Mesh Terms:

KEYWORDS: Polymorphism, Single Nucleotide

MESH TERMS: ethnology

Chemical & Substance for Abstract: Familial Mediterranean fever gene and protection against asthma. Information

Substance Name: DNA

Registry Number: 9007-49-2

Grant and Affiliation Information for Familial Mediterranean fever gene and protection against asthma.

AFFILIATION: Heller Institute of Medical Research, Sheba Medical Center, Tel-Hashomer, Israel.

Country: United States

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MEDLINETA: Ann Allergy Asthma Immunol

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