Familial hemiplegic migraine: a clinical comparison of families linked and unlinked to chromosome 19.DMG RG.

Familial hemiplegic migraine: a clinical comparison of families linked and unlinked to chromosome 19.DMG RG. Research Abstract Details 

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Familial hemiplegic migraine: a clinical comparison of families linked and unlinked to chromosome 19.DMG RG. Abstract Text:

G M Terwindt,R A Ophoff,J Haan,R R Frants,M D Ferrari,

We compared the clinical characteristics of 46 patients from three unrelated families with familial hemiplegic migraine (FHM) linked to chromosome 19, with those of 20 patients from two families with FHM not linked to chromosome 19. We found no significant differences for age at onset, frequency and duration of attacks, duration of the paresis, and occurrence of basilar migraine symptoms. In the linked families, significantly more patients reported unconsciousness during attacks (39% vs 15%; p < 0.05) and provocation of attacks by mild head trauma (70% vs 40%; p < 0.05). In one linked family patients also displayed chronic progressive cerebellar ataxia, whereas in one unlinked family benign infantile convulsions occurred in addition to FHM. Interestingly, so far an association with cerebellar ataxia was only described in chromosome 19-linked families. FHM linked to chromosome 19 and FHM unlinked to chromosome 19 do not differ with respect to clinical features.

Familial hemiplegic migraine: a clinical comparison of families linked and unlinked to chromosome 19.DMG RG. Publishing Authors By Initials

GM Terwindt,RA Ophoff,J Haan,RR Frants,MD Ferrari,

For similar genetic phenomena: phenotype research abstracts see: genetic phenomena: phenotype research

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Familial hemiplegic migraine: a clinical comparison of families linked and unlinked to chromosome 19.DMG RG. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cephalalgia : an international journal of headache

VOLUME: 16

Page Numbers: 153-5

Journal Abbreviation: Cephalalgia

ISSN: 0333-1024

DAY: 11

MONTH: May

YEAR: 1996

Familial hemiplegic migraine: a clinical comparison of families linked and unlinked to chromosome 19.DMG RG. Information

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LANGUAGE: eng

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Familial hemiplegic migraine: a clinical comparison of families linked and unlinked to chromosome 19.DMG RG. Keywords Mesh Terms:

KEYWORDS: Phenotype

MESH TERMS: genetics

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Grant and Affiliation Information for Familial hemiplegic migraine: a clinical comparison of families linked and unlinked to chromosome 19.DMG RG.

AFFILIATION: Department of Neurology, Leiden University Hospital, The Netherlands.

Country: NORWAY

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MEDLINETA: Cephalalgia

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