Familial genes in sporadic disease: common variants of alpha-synuclein gene associate with Parkinson's disease.

Familial genes in sporadic disease: common variants of alpha-synuclein gene associate with Parkinson's disease. Research Abstract Details 

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Familial genes in sporadic disease: common variants of alpha-synuclein gene associate with Parkinson's disease. Abstract Text:

Owen A Ross,David Gosal,Jeremy T Stone,Sarah J Lincoln,Michael G Heckman,G Brent Irvine,Janet A Johnston,J Mark Gibson,Matthew J Farrer,Timothy Lynch,

Genetic variation of the alpha-synuclein gene (SNCA) is known to cause familial parkinsonism, however the role of SNCA variants in sporadic Parkinson's disease (PD) remains elusive. The present study identifies an association of common SNCA polymorphisms with disease susceptibility in a series of Irish PD patients. There is evidence for association with alternate regions, of protection and risk which may act independently/synergistically, within the promoter region (Rep1; OR: 0.59, 95% CI: 0.37-0.84) and the 3'UTR of the gene (rs356165; OR: 1.67, 95% CI: 1.08-2.58). Given previous reports of association a collaborative effort is required which may exploit global linkage disequilibrium patterns for SNCA and standardise polymorphic markers used in each population. It is now crucial to identify the susceptibility allele and elucidate its functionality which may generate a therapeutic target for PD.

Familial genes in sporadic disease: common variants of alpha-synuclein gene associate with Parkinson's disease. Publishing Authors By Initials

OA Ross,D Gosal,JT Stone,SJ Lincoln,MG Heckman,GB Irvine,JA Johnston,JM Gibson,MJ Farrer,T Lynch,

For similar proteins: nerve tissue proteins: synucleins: alpha-synuclein research abstracts see: proteins: nerve tissue proteins: synucleins: alpha-synuclein research

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Familial genes in sporadic disease: common variants of alpha-synuclein gene associate with Parkinson's disease. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Mechanisms of ageing and development

VOLUME: 128

Page Numbers: 378-82

Journal Abbreviation: Mech. Ageing Dev.

ISSN: 0047-6374

DAY: 24

MONTH: 04

YEAR: 2007

Familial genes in sporadic disease: common variants of alpha-synuclein gene associate with Parkinson's disease. Information

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LANGUAGE: eng

NlmUniqueID: 347227

Familial genes in sporadic disease: common variants of alpha-synuclein gene associate with Parkinson's disease. Keywords Mesh Terms:

KEYWORDS: alpha-Synuclein

MESH TERMS: genetics

Chemical & Substance for Abstract: Familial genes in sporadic disease: common variants of alpha-synuclein gene associate with Parkinson's disease. Information

Substance Name: alpha-Synuclein

Registry Number: 0

Grant and Affiliation Information for Familial genes in sporadic disease: common variants of alpha-synuclein gene associate with Parkinson's disease.

AFFILIATION: Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL, USA. ross.owen@mayo.edu

Country: Ireland

AGENCY: United States NINDS

GRANT: P50 #NS40256

ACRONYM: NS

MEDLINETA: Mech Ageing Dev

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