Faithful segregation of the multicopy yeast plasmid through cohesin-mediated recognition of sisters.

Faithful segregation of the multicopy yeast plasmid through cohesin-mediated recognition of sisters. Research Abstract Details 

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Faithful segregation of the multicopy yeast plasmid through cohesin-mediated recognition of sisters. Abstract Text:

Santanu K Ghosh,Sujata Hajra,Makkuni Jayaram,

The 2-microm yeast plasmid, a benign high-copy nuclear parasite, propagates itself with nearly the same fidelity as the chromosomes of its host. Equal plasmid segregation is absolutely dependent on the cohesin complex assembled at the plasmid partitioning locus STB. However, the mechanism of cohesin action in the context of multiple plasmid copies, resident within two separate clusters after DNA replication, is unknown. By using "single-copy" derivatives of the 2-microm plasmid, we demonstrate that recruitment of cohesin at STB during S phase indeed translates into cohesion between plasmid molecules. Through binary fluorescence tagging, we reveal that segregation of replicated plasmids occurs in a sister-to-sister fashion. Thus, cohesin serves the same fundamental purpose in plasmid and chromosome segregation.

Faithful segregation of the multicopy yeast plasmid through cohesin-mediated recognition of sisters. Publishing Authors By Initials

SK Ghosh,S Hajra,M Jayaram,

For similar fungi: yeasts research abstracts see: fungi: yeasts research

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Faithful segregation of the multicopy yeast plasmid through cohesin-mediated recognition of sisters. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 104

Page Numbers: 13034-9

Journal Abbreviation: Proc. Natl. Acad. Sci. U.S.A.

ISSN: 0027-8424

DAY: 1

MONTH: 08

YEAR: 2007

Faithful segregation of the multicopy yeast plasmid through cohesin-mediated recognition of sisters. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7505876

Faithful segregation of the multicopy yeast plasmid through cohesin-mediated recognition of sisters. Keywords Mesh Terms:

KEYWORDS: Yeasts

MESH TERMS: genetics

Chemical & Substance for Abstract: Faithful segregation of the multicopy yeast plasmid through cohesin-mediated recognition of sisters. Information

Substance Name: cohesins

Registry Number: 0

Grant and Affiliation Information for Faithful segregation of the multicopy yeast plasmid through cohesin-mediated recognition of sisters.

AFFILIATION: Section of Molecular Genetics and Microbiology, University of Texas, Austin, TX 78712, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: GM64363

ACRONYM: GM

MEDLINETA: Proc Natl Acad Sci U S A

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