Failed induction of heme oxygenase 1 in endothelial cells exposed to the hemoglobin based oxygen carrier oxyglobin(r).

Failed induction of heme oxygenase 1 in endothelial cells exposed to the hemoglobin based oxygen carrier oxyglobin(r). Research Abstract Details 

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Failed induction of heme oxygenase 1 in endothelial cells exposed to the hemoglobin based oxygen carrier oxyglobin(r). Abstract Text:

Christian Rempf,Arno Ritter,Sonja Schrepfer,Marc Freitag,Thomas Standl,André Gottschalk,Christian Rempf,Arno Ritter,Sonja Schrepfer,Marc Freitag,Thomas Standl, Gottschalk,

We investigated the effect of the bovine hemoglobin based oxygen carrier HBOC-200 (Oxyglobin(R)) in rat aortic endothelial cells (RAEC) on the activation of heme oxygenase 1 (HO-1). RAEC were incubated in the presence of 75 mu M (G1) or 225 mu M (G2) HBOC-200. The positive control (G3) was performed by incubation with 50 mu M Hemin. For negative control (G4) cells were incubated with medium alone. G2 and G3 reached a significant increase of bilirubin concentration compared to G4. A positive HO-1 signal in the Western Blot was seen in G3 12 and 24 h after incubation. The Western Blot of G1, G2 and G4 showed no HO-1 signal. These data suggest that HBOC-200 in the applied dosage cannot induce HO-1 expression in RAEC, and may be degraded by isoenzymes at a lower level.

Failed induction of heme oxygenase 1 in endothelial cells exposed to the hemoglobin based oxygen carrier oxyglobin(r). Publishing Authors By Initials

C Rempf,A Ritter,S Schrepfer,M Freitag,T Standl,A Gottschalk,C Rempf,A Ritter,S Schrepfer,M Freitag,T Standl,A Gottschalk,

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Failed induction of heme oxygenase 1 in endothelial cells exposed to the hemoglobin based oxygen carrier oxyglobin(r). Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Artificial cells, blood substitutes, and immobiliz

VOLUME: 36

Page Numbers: 34-44

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ISSN: 1073-1199

DAY: 22

MONTH: 02

YEAR: 2008

Failed induction of heme oxygenase 1 in endothelial cells exposed to the hemoglobin based oxygen carrier oxyglobin(r). Information

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LANGUAGE: eng

NlmUniqueID: 9431307

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Grant and Affiliation Information for Failed induction of heme oxygenase 1 in endothelial cells exposed to the hemoglobin based oxygen carrier oxyglobin(r).

AFFILIATION: Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, Knappschaftskrankenhaus Bochum Langendreeer, University Hospital, Germany.

Country: United States

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MEDLINETA: Artif Cells Blood Substit Immo

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