Factors responsible for age-related elevation in fasting plasma glucose: a cross-sectional study in Japanese men.

Factors responsible for age-related elevation in fasting plasma glucose: a cross-sectional study in Japanese men. Research Abstract Details 

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Factors responsible for age-related elevation in fasting plasma glucose: a cross-sectional study in Japanese men. Abstract Text:

Kentaro Toyoda,Mitsuo Fukushima,Rie Mitsui,Norio Harada,Hidehiko Suzuki,Tomomi Takeda,Ataru Taniguchi,Yoshikatsu Nakai,Toshiko Kawakita,Yuichiro Yamada,Nobuya Inagaki,Yutaka Seino,Kentaro Toyoda,Mitsuo Fukushima,Rie Mitsui,Norio Harada,Hidehiko Suzuki,Tomomi Takeda,Ataru Taniguchi,Yoshikatsu Nakai,Toshiko Kawakita,Yuichiro Yamada,Nobuya Inagaki,Yutaka Seino,

To evaluate the factors associated with age-related increase in fasting plasma glucose (FPG) in Japanese men with normal fasting glucose, we measured FPG, fasting immunoreactive insulin, glycated hemoglobin, total cholesterol, triglyceride, and high-density lipoprotein cholesterol levels in health check examinees. Subjects with FPG less than 6.1 mmol/L together with glycated hemoglobin less than 5.6% were enrolled in the study. The homeostasis model assessment of insulin resistance (HOMA-IR) and HOMA-beta were used as the indices of insulin sensitivity and insulin secretion, respectively. Fasting plasma glucose increased significantly with age (r = 0.30, P < .0001), and HOMA-beta decreased significantly with age (r = 0.24, P < .0001). The HOMA-IR had no significant relation with age (r = 0.06, not significant), whereas body mass index and serum triglyceride were associated with HOMA-IR (r = 0.49, P < .0001 and r = 0.33, P < .0001, respectively). Thus, in Japanese male subjects with normal fasting glucose, it is suggested that the FPG increment with age is associated with decreased beta-cell function rather than with insulin resistance. Further analyses were performed by comparing 3 groups: low FPG (FPG <5.0 mmol/L), high FPG (5.0

Factors responsible for age-related elevation in fasting plasma glucose: a cross-sectional study in Japanese men. Publishing Authors By Initials

K Toyoda,M Fukushima,R Mitsui,N Harada,H Suzuki,T Takeda,A Taniguchi,Y Nakai,T Kawakita,Y Yamada,N Inagaki,Y Seino,K Toyoda,M Fukushima,R Mitsui,N Harada,H Suzuki,T Takeda,A Taniguchi,Y Nakai,T Kawakita,Y Yamada,N Inagaki,Y Seino,

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Factors responsible for age-related elevation in fasting plasma glucose: a cross-sectional study in Japanese men. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Metabolism: clinical and experimental

VOLUME: 57

Page Numbers: 299-303

Journal Abbreviation: Metab. Clin. Exp.

ISSN: 0026-0495

DAY: 14

MONTH: Feb

YEAR: 2008

Factors responsible for age-related elevation in fasting plasma glucose: a cross-sectional study in Japanese men. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Factors responsible for age-related elevation in fasting plasma glucose: a cross-sectional study in Japanese men.

AFFILIATION: Department of Diabetes and Clinical Nutrition, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.

Country: United States

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MEDLINETA: Metabolism

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