Factors influencing cell fate in the infarct rim.

Factors influencing cell fate in the infarct rim. Research Abstract Details 

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Factors influencing cell fate in the infarct rim. Abstract Text:

Hang Yao,Yousheng Shu,Juan Wang,Brendan C Brinkman,Gabriel G Haddad,

In focal ischemia, the fate of penumbral cells is closely linked to the infarcted tissue. Because of the release of cytosolic material from damaged cells, the biochemical and ionic alterations within the core are dramatic. Hence, adjacent cells ( infarct rim) are generally exposed to these changes and may be deleteriously affected. To mimic such conditions in vitro, we have employed a slice culture system and used an ischemic solution (IS) that resembles the milieu in the territory of infarct rim. In contrast to normal artificial cerebral spinal fluid, IS is characterized by low O(2), glucose, pH; excitotoxic levels of glutamate; and ionic alterations. In organotypic hippocampal slice cultures, we examined cell injury/death using propidium iodide following exposure to IS. Our data show significant cell injury starting at approximately 8 h following IS exposure with cell injury spreading as a function of exposure duration. We further studied the effect of each component in the IS separately, i.e., acidosis, hypoxia, ionic shifts or glutamate exitotoxicity and were able to isolate the contribution of each of these effectors to the IS-induced cell death. Our results suggest that in IS, acidosis exacerbates the potential for injury while ionic shifts, especially those of K(+) and Na(+), alleviate the potential for cell death.

Factors influencing cell fate in the infarct rim. Publishing Authors By Initials

H Yao,Y Shu,J Wang,BC Brinkman,GG Haddad,

For similar environment and public health: environment: environment, controlled: temperature research abstracts see: environment and public health: environment: environment, controlled: temperature research

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Factors influencing cell fate in the infarct rim. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of neurochemistry

VOLUME: 100

Page Numbers: 1224-33

Journal Abbreviation: J. Neurochem.

ISSN: 0022-3042

DAY: 8

MONTH: 01

YEAR: 2007

Factors influencing cell fate in the infarct rim. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2985190

Factors influencing cell fate in the infarct rim. Keywords Mesh Terms:

KEYWORDS: Temperature

MESH TERMS: metabolism

Chemical & Substance for Abstract: Factors influencing cell fate in the infarct rim. Information

Substance Name: Oxygen

Registry Number: 7782-44-7

Grant and Affiliation Information for Factors influencing cell fate in the infarct rim.

AFFILIATION: Department of Pediatrics, University of California, San Diego, La Jolla, California 92093-0735, USA.

Country: England

AGENCY: United States NHLBI

GRANT: R01 HL 66237

ACRONYM: HL

MEDLINETA: J Neurochem

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