Factors affecting drug concentrations and QT interval during thioridazine therapy.

Factors affecting drug concentrations and QT interval during thioridazine therapy. Research Abstract Details 

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Factors affecting drug concentrations and QT interval during thioridazine therapy. Abstract Text:

R H K Thanacoody,A K Daly,J G Reilly,I N Ferrier,S H L Thomas,

The objective of this study was to investigate factors affecting steady-state plasma concentrations of thioridazine. A cross-sectional study of patients receiving chronic thioridazine was employed. Common allelic variants of CYP2D6 and CYP2C19, as well as thioridazine and metabolite concentrations and QTc intervals, were determined. In 97 patients, dose-corrected plasma concentrations (C/Ds) of thioridazine and metabolites were correlated with age but not sex or CYP2C19 genotype. Patients with no functional CYP2D6 alleles (n=9) had significantly higher C/D for thioridazine (P=0.017) and the ring sulfoxide metabolite and a significantly higher thioridazine/mesoridazine ratio compared with those with >/=1 functional CYP2D6 allele (n=82). Smokers had significantly lower C/D for thioridazine, mesoridazine, and sulforidazine and significantly lower thioridazine/ring sulfoxide ratios than non-smokers. QTc interval was not significantly affected by CYP2D6 or CYP2C19 genotypes. Plasma concentrations of thioridazine are influenced by age, smoking, and CYP2D6 genotype, but CYP2D6 genotype does not appear to influence on-treatment QTc interval.

Factors affecting drug concentrations and QT interval during thioridazine therapy. Publishing Authors By Initials

RH Thanacoody,AK Daly,JG Reilly,IN Ferrier,SH Thomas,

For similar genetic phenomena: variation (genetics) research abstracts see: genetic phenomena: variation (genetics) research

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Factors affecting drug concentrations and QT interval during thioridazine therapy. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Clinical pharmacology and therapeutics

VOLUME: 82

Page Numbers: 555-65

Journal Abbreviation: Clin. Pharmacol. Ther.

ISSN: 1532-6535

DAY: 25

MONTH: 04

YEAR: 2007

Factors affecting drug concentrations and QT interval during thioridazine therapy. Information

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LANGUAGE: eng

NlmUniqueID: 372741

Factors affecting drug concentrations and QT interval during thioridazine therapy. Keywords Mesh Terms:

KEYWORDS: Variation (Genetics)

MESH TERMS: pharmacokinetics

Chemical & Substance for Abstract: Factors affecting drug concentrations and QT interval during thioridazine therapy. Information

Substance Name: Cytochrome P-450 CYP2D6

Registry Number: EC 1.14.14.1

Grant and Affiliation Information for Factors affecting drug concentrations and QT interval during thioridazine therapy.

AFFILIATION: School of Clinical and Laboratory Sciences, University of Newcastle, Newcastle upon Tyne, UK.

Country: United States

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MEDLINETA: Clin Pharmacol Ther

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