Facile C-N cleavage in a series of bridged lactams.

Facile C-N cleavage in a series of bridged lactams. Research Abstract Details 

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Facile C-N cleavage in a series of bridged lactams. Abstract Text:

Yao Lei,Aaron D Wrobleski,Jennifer E Golden,Douglas R Powell,Jeffrey ,

A series of strained bi- and tricyclic amides has been shown to be unusually sensitive to cleavage of the C-N bond adjacent to the amide moiety. This bond undergoes facile breaking when subjected to treatment with H2/Pd(OH)2, MeI, and DDQ. In each case, the reaction is highly regioselective and mainly results in breaking the C-N bond that deviates the farthest from its natural planar state. Preliminary experiments that bear on the mechanisms of these reactions are described.

Facile C-N cleavage in a series of bridged lactams. Publishing Authors By Initials

Y Lei,AD Wrobleski,JE Golden,DR Powell,J ,

For similar biochemical phenomena, metabolism, and nutrition: biochemical phenomena: molecular structure: molecular conformation research abstracts see: biochemical phenomena, metabolism, and nutrition: biochemical phenomena: molecular structure: molecular conformation research

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Facile C-N cleavage in a series of bridged lactams. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of the American Chemical Society

VOLUME: 127

Page Numbers: 4552-3

Journal Abbreviation: J. Am. Chem. Soc.

ISSN: 0002-7863

DAY: 6

MONTH: Apr

YEAR: 2005

Facile C-N cleavage in a series of bridged lactams. Information

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LANGUAGE: eng

NlmUniqueID: 7503056

Facile C-N cleavage in a series of bridged lactams. Keywords Mesh Terms:

KEYWORDS: Molecular Conformation

MESH TERMS: chemistry

Chemical & Substance for Abstract: Facile C-N cleavage in a series of bridged lactams. Information

Substance Name: Lactams

Registry Number: 0

Grant and Affiliation Information for Facile C-N cleavage in a series of bridged lactams.

AFFILIATION: Department of Medicinal Chemistry, 1251 Wescoe Hall Drive, Room 4070, Malott Hall, University of Kansas, Lawrence, KS 66045-7582, USA.

Country: United States

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MEDLINETA: J Am Chem Soc

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