Facile Access to Polysubstituted Indoles via a Cascade Cu-Catalyzed Arylation-Condensation Process.

Facile Access to Polysubstituted Indoles via a Cascade Cu-Catalyzed Arylation-Condensation Process. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Facile Access to Polysubstituted Indoles via a Cascade Cu-Catalyzed Arylation-Condensation Process. Abstract Text:

Yu Chen,Xiaoan Xie,Dawei Ma,Yu Chen,Xiaoan Xie,Dawei Ma,

CuI/l-proline-catalyzed cross-coupling of 2-halotrifluoroacetanilides with beta-keto esters and amides followed by in situ acidic hydrolysis delivered 2,3-disubstituted indoles. The halides bearing a strong electron-withdrawing group in the 4-position can undergo in situ basic hydrolysis to provide the corresponding indoles. Polysubstituted indoles can be prepared from substituted 2-halotrifluoroacetanilides with high regioselectivity.

Facile Access to Polysubstituted Indoles via a Cascade Cu-Catalyzed Arylation-Condensation Process. Publishing Authors By Initials

Y Chen,X Xie,D Ma,Y Chen,X Xie,D Ma,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Facile Access to Polysubstituted Indoles via a Cascade Cu-Catalyzed Arylation-Condensation Process. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Journal of organic chemistry

VOLUME: 72

Page Numbers: 9329-34

Journal Abbreviation: J. Org. Chem.

ISSN: 0022-3263

DAY: 2

MONTH: 11

YEAR: 2007

Facile Access to Polysubstituted Indoles via a Cascade Cu-Catalyzed Arylation-Condensation Process. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2985193

Facile Access to Polysubstituted Indoles via a Cascade Cu-Catalyzed Arylation-Condensation Process. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Facile Access to Polysubstituted Indoles via a Cascade Cu-Catalyzed Arylation-Condensation Process. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Facile Access to Polysubstituted Indoles via a Cascade Cu-Catalyzed Arylation-Condensation Process.

AFFILIATION: Department of Chemistry, Fudan University, Shanghai 200433, China, and State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Org Chem

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Facile Access to Polysubstituted Indoles via a Cascade Cu-Catalyzed Arylation-Condensation Process Related Publications

• Changes in potassium currents of vascular smooth muscle cells from hindquarter arteries of 4-wk simulated weightlessness rats.
• Changes of angiotensinogen expression in arteries of tail-suspended rats.
• Cyclooxyenase-2 expression in endometrium carcinoma.
• Expression of intestinal mucin antigens in the gastric epithelium and its relationship with malignancy.
• Intestinal metaplasia and gastric carcinoma. A histochemical and immunohistochemical study.
• Intestinal mucin antigens in ulcerative colitis and their relationship with malignancy.
• Significance and expression of vascular endothelial growth factor and E-cadherin in non-small cell lung Carcinomas.
• [Advances in affinity chromatography]
• [Alteration of the expression of cartilage matrix molecule in the cartilage by the chondrocytes from rabbit temporomandibular joint with experimental osteoarthritis and its response to interleukin-1 beta]
• [Application of sensitivity analysis method in mode analysis of hypergravitation training facility]
• [Changes in potassium currents of vascular smooth muscle cells isolated from hindquarter arteries of rats after 4 weeks simulated weightlessness]
• [Cloning and sequencing of cDNA of E2/NS1 gene of hepatitis C virus]
• [Construction of PTTGas antisense expression vector and its inhibitory effects on human ovarian carcinoma cell line SK-OV-3]
• [Current status and prospect of critical care medicine in Western Pacific countries and regions: summary of 13th Western Pacific Congress on Critical Care Medicine]
• [Dynamic changes in the expression of type VI collagen in mice with schistosomal liver fibrosis]
• [Effectiveness of para-aortic lymph node dissection for advanced gastric cancer]
• [Effects of hindlimb unloading on bone histomorphometry and bone mass in rats]
• [Expression of Japanese encephalitis virus E protein in methylotrophic yeast Pichia pastoris]
• [Human bone morphogenetic protein-2: recombinant expression in E. coli]
• [In silico data mining of the human programmed cell death 5 (PDCD5) sequences]
• [Observation on micronuclei incidence of peripheral blood lymphocyte in attendants diesel locomotive and wheel axle workers]
• [Relation between COX-2 protein expression and biologic behavior of ovarian carcinoma]
• [Relationship between hygienic habit and parasitic infection]
• [Relationship between type I autoimmune hepatitis and alleles of HLA-DRB1 in Chinese patients of Shanghai area]
• [Separation of p-aminobenzenearsonic acid and its oxide by ion-pair reversed-phase high performance liquid chromatography]
• [Simvastatin induces osteoblastic differentiation of bone marrow stromal cells]
• [Sutural distraction osteogenesis for primary cleft palate repair: a preliminary clinical report]
• [The diagnostic value of platelet glycoprotein-specific autoantibody detection in autoimmune thrombocytopenic purpura]
• [The role of activation of nuclear factor-kappa B of rat brain in the pathogenesis of experimental allergic encephalomyelitis]
• [The study of low dose radiation inducing hormesis effect on hematopoietic system]