Fabrication of an Optimal Urethral Graft Using Collagen-Sponge Tubes Reinforced with Copoly(L-Lactide/epsilon-Caprolactone) Fabric.

Fabrication of an Optimal Urethral Graft Using Collagen-Sponge Tubes Reinforced with Copoly(L-Lactide/epsilon-Caprolactone) Fabric. Research Abstract Details 

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Fabrication of an Optimal Urethral Graft Using Collagen-Sponge Tubes Reinforced with Copoly(L-Lactide/epsilon-Caprolactone) Fabric. Abstract Text:

Isao Kanatani,Akihiro Kanematsu,Yasuyuki Inatsugu,Masaaki Imamura,Hiromitsu Negoro,Noriyuki Ito,Shingo Yamamoto,Yasuhiko Tabata,Yoshito Ikada,Osamu Ogawa,Isao Kanatani,Akihiro Kanematsu,Yasuyuki Inatsugu,Masaaki Imamura,Hiromitsu Negoro,Noriyuki Ito,Shingo Yamamoto,Yasuhiko Tabata,Yoshito Ikada,Osamu Ogawa,Isao Kanatani,Akihiro Kanematsu,Yasuyuki Inatsugu,Masaaki Imamura,Hiromitsu Negoro,Noriyuki Ito,Shingo Yamamoto,Yasuhiko Tabata,Yoshito Ikada,Osamu Ogawa,

An ideal biomaterial for urethral reconstruction has not been developed. To create a urethral graft biomaterial with optimal biodegradability and biocompatibility, a copoly(L-lactide/epsilon-caprolactone) [P(LA/CL)] fabric tube was combined with a type I collagen sponge. The P(LA/CL) fibers were knitted into a vascular stent style (Type 1) or weaved into a mesh style (Type 2) to prepare P(LA/CL) tubes. The tubes were dipped in aqueous collagen solution and lyophilyzed to prepare the P(LA/CL)-collagen sponge graft. The grafts were applied to a 1.5-cm rabbit urethral defect (n = 14 for each condition), and tissue repair was evaluated using urethrographical, urethroscopical, and histological examination 1, 3, and 6 months after surgery. Although epithelialization was observed after 1 month in all Type 1 grafts, stenoses, fistulae, or stone formation was seen in 7 of the rabbits. In some cases, P(LA/CL) fibers prolapsed into the urethral lumen, causing stone formation. Only 3 rabbits survived for 6 months, and 2 of these had stenoses. For the Type 2 graft, all urethras were patent, without fistulae or stenoses, over the entire observation period. Histologically, urethral structure was disorganized for the Type 1 graft, whereas the urethral tissue on the Type 2 graft was slightly fibrotic but completely epithelialized and supported by a regenerated smooth muscle layer at 6 months. These findings suggest that creation of a scaffold suitable for urethral tissue regeneration will depend not only on the biomaterial composition, but also on the fabrication technique.

Fabrication of an Optimal Urethral Graft Using Collagen-Sponge Tubes Reinforced with Copoly(L-Lactide/epsilon-Caprolactone) Fabric. Publishing Authors By Initials

I Kanatani,A Kanematsu,Y Inatsugu,M Imamura,H Negoro,N Ito,S Yamamoto,Y Tabata,Y Ikada,O Ogawa,I Kanatani,A Kanematsu,Y Inatsugu,M Imamura,H Negoro,N Ito,S Yamamoto,Y Tabata,Y Ikada,O Ogawa,I Kanatani,A Kanematsu,Y Inatsugu,M Imamura,H Negoro,N Ito,S Yamamoto,Y Tabata,Y Ikada,O Ogawa,

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Fabrication of an Optimal Urethral Graft Using Collagen-Sponge Tubes Reinforced with Copoly(L-Lactide/epsilon-Caprolactone) Fabric. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Tissue engineering

VOLUME: 13

Page Numbers: 2933-40

Journal Abbreviation: Tissue Eng.

ISSN: 1076-3279

DAY: 10

MONTH: Dec

YEAR: 2007

Fabrication of an Optimal Urethral Graft Using Collagen-Sponge Tubes Reinforced with Copoly(L-Lactide/epsilon-Caprolactone) Fabric. Information

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LANGUAGE: eng

NlmUniqueID: 9505538

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AFFILIATION: Department of Urology, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan.

Country: United States

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MEDLINETA: Tissue Eng

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