[Eye diseases in mitochondrial encephalomyopathies]

[Eye diseases in mitochondrial encephalomyopathies] Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

[Eye diseases in mitochondrial encephalomyopathies] Abstract Text:

D Mojon,

Mitochondria are the principal site of generation of energy in form of adenosine triphosphate (ATP). They contain the enzymes of the Krebs and fatty acid cycles and the respiratory pathway. Ocular tissues with high energy consumption and dependence on oxidative energy production like the optic nerve, the retina, and the pigment epithelium are often involved in mitochondrial diseases. This article reviews the genetic mitochondrial diseases involving the visual system. Their most important ocular findings include: acute or slowly progressive bilateral visual loss and visual field loss due to an optic neuropathy or retinal degeneration, bilateral progressive decreased ocular motility, and bilateral upper lid ptosis. The following diseases are discussed: Leber's Hereditary Optic Neuropathy (LHON); Kearns-Sayre Syndrom (KSS); Chronic Progressive External Ophthalmoplegia (CPEO); Autosomal Recessive Cardiomyopathy, Ophthalmoplegia (ARCO); Mitochondrial Encephalomyopathy, Lactic Acidosis, Stroke-Like Episodes (MELAS); Neuropathy, Ataxia, Retinitis Pigmentosa (NARP); Mitochondrial Neuropathy, Gastro-Intestinal Encephalomyopathy (MNGIE); Myoclonus Epilepsy, Ragged-Red-Fibers (MERRF); Wilson's disease; Friedreich's ataxia. Diagnosis of mitochondrial encephalomyopathies is established by screening for mutations in blood or muscle biopsy samples. No specific therapies which influence the course of mitochondrial encephalomyopathies are known. Drugs interacting with the mitochondria function, alcohol consumption and smoking should be avoided.

[Eye diseases in mitochondrial encephalomyopathies] Publishing Authors By Initials

D Mojon,

For similar pathological conditions, signs and symptoms: pathologic processes: disease: syndrome research abstracts see: pathological conditions, signs and symptoms: pathologic processes: disease: syndrome research

PUBMED ID PMID:

MEDLINE DATE:

[Eye diseases in mitochondrial encephalomyopathies] Journal Published:

PUBLICATION TYPE: Review

Journal: Therapeutische Umschau. Revue thérapeutique

VOLUME: 58

Page Numbers: 49-55

Journal Abbreviation:

ISSN: 0040-5930

DAY: 12

MONTH: Jan

YEAR: 2001

[Eye diseases in mitochondrial encephalomyopathies] Information

Number of References: 13

LANGUAGE: ger

NlmUniqueID: 407224

[Eye diseases in mitochondrial encephalomyopathies] Keywords Mesh Terms:

KEYWORDS: Syndrome

MESH TERMS: genetics

Chemical & Substance for Abstract: [Eye diseases in mitochondrial encephalomyopathies] Information

Substance Name:

Registry Number:

Grant and Affiliation Information for [Eye diseases in mitochondrial encephalomyopathies]

AFFILIATION: Abteilung für Schielbehandlung und Neuroophthalmologie, Augenklinik, Kantonsspital St. Gallen. daniel.mojon@kssg.ch

Country: Switzerland

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Ther Umsch

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Eye diseases in mitochondrial encephalomyopathies Related Publications

• Central corneal thickness measurements in patients with normal tension glaucoma, primary open angle glaucoma, pseudoexfoliation glaucoma, or ocular hypertension.
• Impact of low vision on well-being in 10 European countries.
• Improved diagnosis of strongyloides stercoralis by seven consecutive stool specimens.
• Opinions of dating agents about strabismic subjects' ability to find a partner.
• Performance of a new, 3D-monitor based random-dot stereotest for children under 4 years of age.
• The microscopic diagnosis of Pneumocystis carinii. An evaluation of the gram, the methylene blue, and the Ziehl-Neelsen procedures.
• [Eye diseases in mitochondrial encephalomyopathies]
• [Eye diseases in sleep apnea syndrome]