Extrinsic and intrinsic factors relating to intimal thickening in children.

Extrinsic and intrinsic factors relating to intimal thickening in children. Research Abstract Details 

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Extrinsic and intrinsic factors relating to intimal thickening in children. Abstract Text:

Children already have intimal thickenings occupying over half of the vascular lumen. Intimal thickening is one of the first steps in atherogenesis. Classical risk factors such as hypercholesterolaemia, genetic background and acute noxious factors play a role in its development. Genetic origin of the children from high-risk groups for coronary heart disease seems to be a determinant of the magnitude of thickenings. Extrinsic factors such as infections also seem to play a role. The magnitude of the thickening is related to viral and bacterial infections. Infections may lead to endothelial injury and secondary intimal thickening. The process may advance stepwise with acute exacerbations of endothelial dysfunction and intimal thickening followed by incomplete healing. In particular, repeated acute infections might lead to permanent damage. Morphological evidence for early atherogenesis in children is presented.

Extrinsic and intrinsic factors relating to intimal thickening in children. Publishing Authors By Initials

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Extrinsic and intrinsic factors relating to intimal thickening in children. Journal Published:

PUBLICATION TYPE: Review

Journal: Acta paediatrica (Oslo, Norway : 1992). Supplement

VOLUME: 93

Page Numbers: 43-7

Journal Abbreviation: Acta Paediatr Suppl

ISSN: 0803-5326

DAY: 12

MONTH: Dec

YEAR: 2004

Extrinsic and intrinsic factors relating to intimal thickening in children. Information

Number of References: 37

LANGUAGE: eng

NlmUniqueID: 9315043

Extrinsic and intrinsic factors relating to intimal thickening in children. Keywords Mesh Terms:

KEYWORDS: Virus Diseases

MESH TERMS: complications

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Grant and Affiliation Information for Extrinsic and intrinsic factors relating to intimal thickening in children.

AFFILIATION: Department of Paediatric Cardiology, Lund University Hospital, Lund, Sweden. erkki.pesonen@skane.se

Country: Norway

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MEDLINETA: Acta Paediatr Suppl

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