Extrathyroidal synthesis and biologic action of thyroid receptor antibody (TRAb) in Graves' disease.

Extrathyroidal synthesis and biologic action of thyroid receptor antibody (TRAb) in Graves' disease. Research Abstract Details 

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Extrathyroidal synthesis and biologic action of thyroid receptor antibody (TRAb) in Graves' disease. Abstract Text:

R Paschke,H G Heinze,J Teuber,R Schmeidl,K H Usadel,

In a patient with Graves' disease who underwent thyroidectomy with subsequent radioiodine therapy thyroid receptor antibody could be detected by radioligand assay. No thyroid tissue could be detected by 131I-scintiscanning. Thyroglobulin was repeatedly negative. Biologic activity of this patients serum could be demonstrated in the nude mice bio assay. 131I-incorporation and secretion of human thyroglobulin could be stimulated by injecting thymusdysplastic nude mice with transplants of thyroid tissue from a patient with Graves' disease with the athyroid patients serum. These results demonstrate evidence for extrathyroidal production and biological activity of TRAb in vivo.

Extrathyroidal synthesis and biologic action of thyroid receptor antibody (TRAb) in Graves' disease. Publishing Authors By Initials

R Paschke,HG Heinze,J Teuber,R Schmeidl,KH Usadel,

For similar surgical procedures, operative: endocrine surgical procedures: thyroidectomy research abstracts see: surgical procedures, operative: endocrine surgical procedures: thyroidectomy research

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Extrathyroidal synthesis and biologic action of thyroid receptor antibody (TRAb) in Graves' disease. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Acta endocrinologica. Supplementum

VOLUME: 281

Page Numbers: 352-4

Journal Abbreviation:

ISSN: 0300-9750

DAY: 12

MONTH: 02

YEAR: 1987

Extrathyroidal synthesis and biologic action of thyroid receptor antibody (TRAb) in Graves' disease. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 370313

Extrathyroidal synthesis and biologic action of thyroid receptor antibody (TRAb) in Graves' disease. Keywords Mesh Terms:

KEYWORDS: Thyroidectomy

MESH TERMS: analysis

Chemical & Substance for Abstract: Extrathyroidal synthesis and biologic action of thyroid receptor antibody (TRAb) in Graves' disease. Information

Substance Name: Thyroglobulin

Registry Number: 9010-34-8

Grant and Affiliation Information for Extrathyroidal synthesis and biologic action of thyroid receptor antibody (TRAb) in Graves' disease.

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Country: DENMARK

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MEDLINETA: Acta Endocrinol Suppl (Copenh)

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