Extracellular signal-regulated kinase 1/2 involvement in the enhancement of contextual fear conditioning by nicotine.

Extracellular signal-regulated kinase 1/2 involvement in the enhancement of contextual fear conditioning by nicotine. Research Abstract Details 

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Extracellular signal-regulated kinase 1/2 involvement in the enhancement of contextual fear conditioning by nicotine. Abstract Text:

Jonathan D Raybuck,Thomas J Gould,

Contextual fear conditioning is enhanced by nicotine, but the cellular mechanisms underlying this effect are unknown. Extracellular signal regulated kinase 1/2 (ERK 1/2) has been shown to play an integral role in the formation of contextual fear memories. As such, it is possible that ERK 1/2 is involved in the enhancement of contextual fear conditioning by nicotine. To determine whether ERK 1/2 plays a role in this enhancement, a dose of SL327 (a selective, systemic ERK 1/2 inhibitor) that is subthreshold for inhibiting contextual fear conditioning was coadministered with nicotine prior to training, testing, or both training and testing of contextual fear conditioning in C57BL/6 mice. When administered prior to training, this subthreshold dose of SL327 attenuated the enhancement of contextual fear conditioning by nicotine to levels similar to those of vehicle-treated animals. When administered prior to testing, the subthreshold dose of SL327 did not significantly alter conditioning. These results suggest that activation of ERK 1/2 by nicotine during acquisition leads to an enhancement of contextual fear conditioning.

Extracellular signal-regulated kinase 1/2 involvement in the enhancement of contextual fear conditioning by nicotine. Publishing Authors By Initials

JD Raybuck,TJ Gould,

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Extracellular signal-regulated kinase 1/2 involvement in the enhancement of contextual fear conditioning by nicotine. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Behavioral neuroscience

VOLUME: 121

Page Numbers: 1119-24

Journal Abbreviation: Behav. Neurosci.

ISSN: 0735-7044

DAY: 20

MONTH: Oct

YEAR: 2007

Extracellular signal-regulated kinase 1/2 involvement in the enhancement of contextual fear conditioning by nicotine. Information

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LANGUAGE: eng

NlmUniqueID: 8302411

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Grant and Affiliation Information for Extracellular signal-regulated kinase 1/2 involvement in the enhancement of contextual fear conditioning by nicotine.

AFFILIATION: Department of Psychology, Temple University, Philadelphia, PA 19122, USA.

Country: United States

AGENCY: United States NIDA

GRANT: T32DA07237

ACRONYM: DA

MEDLINETA: Behav Neurosci

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